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    tsu tsunagi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsuprovided by FlyBase
    Official Full Name
    tsunagiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033378
    Locus tag
    Dmel_CG8781
    See related
    AllianceGenome:FB:FBgn0033378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8781; CG8781; Dmel\CG8781; dY14; Tsu; TSU; y14; Y14; Y14/Tsunagi
    Summary
    Predicted to enable mRNA binding activity. Involved in several processes, including RNA splicing; oocyte differentiation; and regulation of pole plasm oskar mRNA localization. Located in cytoplasm and nucleus. Part of exon-exon junction complex. Is expressed in embryonic brain; larval ventral nerve cord; oocyte; and organism. Human ortholog(s) of this gene implicated in thrombocytopenia-absent radius syndrome. Orthologous to human RBM8A (RNA binding motif protein 8A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tsu in Genome Data Viewer
    Location:
    45A7-45A7; 2-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9110799..9111578)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4998304..4999083)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Van Gogh Neighboring gene Phosphoglucomutase 2a Neighboring gene Mystery 45A Neighboring gene Phosphorylated adaptor for RNA export Neighboring gene Suppressor of variegation 2-10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the Drosophila Mago nashi-Y14 complex. Shi H, et al. Genes Dev, 2003 Apr 15. PMID 12704080, Free PMC Article
    2. A yeast functional screen predicts new candidate ALS disease genes. Couthouis J, et al. Proc Natl Acad Sci U S A, 2011 Dec 27. PMID 22065782, Free PMC Article
    3. How introns influence and enhance eukaryotic gene expression. Le Hir H, et al. Trends Biochem Sci, 2003 Apr. PMID 12713906
    4. A novel mode of RBD-protein recognition in the Y14-Mago complex. Fribourg S, et al. Nat Struct Biol, 2003 Jun. PMID 12730685
    5. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Hachet O, et al. Nature, 2004 Apr 29. PMID 15118729

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tsunagi/Y14 forms compllex with Mago Nashi and Ranshi protein that influences oocyte differentiation in Drosophila melanogaster.
      Title: Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster.
    2. Tsunagi/Y14 is essential for restricting oocyte fate to a single cell and may function with mago nashi in this process.
      Title: Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification.
    3. We have determined the crystal structure of the complex between Drosophila melanogaster Y14 and Mago at a resolution of 2.5 A. The structure reveals an atypical mode of protein-protein recognition mediated by an RNA-binding domain (RBD).
      Title: A novel mode of RBD-protein recognition in the Y14-Mago complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of pole plasm mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germarium-derived oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte nucleus localization involved in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tsunagi
    Names
    CG8781-PA
    Y14
    tsu-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9110799..9111578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136610.4 → NP_610454.2  tsunagi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610454.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZA6, Q95X08, Q9V535
      UniProtKB/TrEMBL
      F2FB57
      Related
      FBpp0087648
      Conserved Domains (2) summary
      cd12324
      Location:67 → 154
      RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins
      cl01709
      Location:10 → 80
      PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V535.1 Q9V535

    Gene LinkOut

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    Other Literature Sources
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