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    reb rebuf [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rebprovided by FlyBase
    Official Full Name
    rebufprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033667
    Locus tag
    Dmel_CG13183
    See related
    AllianceGenome:FB:FBgn0033667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13183; Dmel\CG13183; Reb
    Summary
    Involved in chitin-based embryonic cuticle biosynthetic process and trachea morphogenesis. Located in apical part of cell and cytoplasm. Is active in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including dorsal epidermis primordium; embryonic head epidermis; embryonic hypopharynx; embryonic ventral epidermis; and epithelium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See reb in Genome Data Viewer
    Location:
    48C5-48D2; 2-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11904323..11912779, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7791828..7800284, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene Microcephalin Neighboring gene Zinc/iron regulated transporter-related protein 48C Neighboring gene long non-coding RNA:CR44305 Neighboring gene long non-coding RNA:CR44312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering the genetic programme triggering timely and spatially-regulated chitin deposition. Moussian B, et al. PLoS Genet, 2015 Jan. PMID 25617778, Free PMC Article
    2. Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold. Beich-Frandsen M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Apr. PMID 25849395, Free PMC Article
    3. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila. De Giorgio E, et al. PLoS Biol, 2023 Jan. PMID 36689563, Free PMC Article
    4. rebuff regulates apical luminal matrix to control tube size in Drosophila trachea. Chandran RR, et al. Biol Open, 2018 Sep 5. PMID 30185423, Free PMC Article
    5. The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size. Iordanou E, et al. Dev Biol, 2014 Sep 1. PMID 24973580, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
      Title: A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rebuf
    Names
    CG13183-PA
    reb-PA
    rebuff

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11904323..11912779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136869.3 → NP_610713.2  rebuf [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610713.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8Q9
      Related
      FBpp0087160
      Conserved Domains (1) summary
      smart00524
      Location:53 → 220
      DWB; Domain B in dwarfin family proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8Q9 A1Z8Q9
    Q8SYD6 Q8SYD6

    Gene LinkOut

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