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    CG8646 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8646provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033763
    Locus tag
    Dmel_CG8646
    See related
    AllianceGenome:FB:FBgn0033763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8646
    Summary
    Predicted to enable sulfuric ester hydrolase activity. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; hindgut proper primordium; posterior endoderm; and ring gland primordium. Orthologous to human ARSI (arylsulfatase family member I) and ARSJ (arylsulfatase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8646 in Genome Data Viewer
    Location:
    49B11-49B11; 2-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12655954..12659341)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8543459..8546846)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zinc transporter 49B Neighboring gene no extended memory Neighboring gene Glutaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amplification of the 1731 LTR retrotransposon in Drosophila melanogaster cultured cells: origin of neocopies and impact on the genome. Maisonhaute C, et al. Gene, 2007 May 15. PMID 17382490
    2. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Jansen IE, et al. Genome Biol, 2017 Jan 30. PMID 28137300, Free PMC Article
    3. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
    4. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
    5. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8646-PB
    NP_610807.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12655954..12659341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136963.4 → NP_610807.3  uncharacterized protein Dmel_CG8646 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610807.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z937, Q8SZ72
      Conserved Domains (3) summary
      COG3119
      Location:25 → 459
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:26 → 405
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
      cl20644
      Location:462 → 531
      DUF4976; Domain of unknown function (DUF4976)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ72 Q8SZ72

    Gene LinkOut

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