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    Agps Alkylglycerone phosphate synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agpsprovided by FlyBase
    Official Full Name
    Alkylglycerone phosphate synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033983
    Locus tag
    Dmel_CG10253
    See related
    AllianceGenome:FB:FBgn0033983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADPS; AGPS; CG10253; dAGPS; Dmel\CG10253
    Summary
    Predicted to enable FAD binding activity and alkylglycerone-phosphate synthase activity. Predicted to be involved in ether lipid biosynthetic process. Located in peroxisome. Is expressed in several structures, including adult head; central brain primordium; embryonic anal pad; ganglia; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata and rhizomelic chondrodysplasia punctata type 3. Orthologous to human AGPS (alkylglycerone phosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Agps in Genome Data Viewer
    Location:
    51D3-51D3; 2-73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14929703..14934861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10817208..10822366, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 6a8 Neighboring gene Cytochrome P450 317a1 Neighboring gene kank Neighboring gene uncharacterized protein Neighboring gene Lap1 Neighboring gene uncharacterized protein Neighboring gene atypical protein kinase C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying a recombinant alkyldihydroxyacetonephosphate synthase suited for crystallographic studies. Razeto A, et al. Protein Expr Purif, 2007 Oct. PMID 17601746
    2. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
    3. New regulators of Drosophila eye development identified from temporal transcriptome changes. Quiquand M, et al. Genetics, 2021 Apr 15. PMID 33681970, Free PMC Article
    4. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Rahman A, et al. Cell Rep, 2022 May 31. PMID 35649355, Free PMC Article
    5. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alkylglycerone-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkylglycerone-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alkylglycerone-phosphate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alkylglycerone phosphate synthase
    Names
    Agps-PA
    Agps-PB
    Agps-PC
    Agps-PD
    CG10253-PA
    CG10253-PB
    CG10253-PC
    CG10253-PD
    alkyldihydroxyacetonephosphate synthase
    NP_001188935.1
    NP_001188936.1
    NP_001188937.1
    NP_611006.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14929703..14934861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202007.2 → NP_001188936.1  alkylglycerone phosphate synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD21, Q9V778
      UniProtKB/TrEMBL
      D5SHU3
      Conserved Domains (3) summary
      COG0277
      Location:152 → 612
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:159 → 300
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:337 → 608
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    2. NM_001202006.1 → NP_001188935.1  alkylglycerone phosphate synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD21, Q9V778
      UniProtKB/TrEMBL
      D5SHU3
      Conserved Domains (3) summary
      COG0277
      Location:152 → 612
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:159 → 300
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:337 → 608
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    3. NM_001202008.1 → NP_001188937.1  alkylglycerone phosphate synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD21, Q9V778
      UniProtKB/TrEMBL
      D5SHU3
      Conserved Domains (3) summary
      COG0277
      Location:152 → 612
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:159 → 300
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:337 → 608
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    4. NM_137162.3 → NP_611006.1  alkylglycerone phosphate synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD21, Q9V778
      UniProtKB/TrEMBL
      D5SHU3
      Related
      FBpp0086558
      Conserved Domains (3) summary
      COG0277
      Location:152 → 612
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:159 → 300
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:337 → 608
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD21 A0A0B4JD21
    Q9V778.1 Q9V778

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