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    Spn53F Serpin 53F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn53Fprovided by FlyBase
    Official Full Name
    Serpin 53Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034195
    Locus tag
    Dmel_CG10956
    See related
    AllianceGenome:FB:FBgn0034195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10956; Dmel\CG10956
    Summary
    Involved in sexual reproduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn53F in Genome Data Viewer
    Location:
    53F12-53F12; 2-81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17122898..17124237, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13010403..13011742, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Amylase proximal Neighboring gene antisense RNA:CR45272 Neighboring gene Amylase distal Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serpins in arthropod biology. Meekins DA, et al. Semin Cell Dev Biol, 2017 Feb. PMID 27603121, Free PMC Article
    2. Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes. Kohn MH, et al. Mol Biol Evol, 2004 Feb. PMID 14660692
    3. Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster. Ravi Ram K, et al. Proc Natl Acad Sci U S A, 2006 Dec 5. PMID 17116868, Free PMC Article
    4. An ectopic expression screen reveals the protective and toxic effects of Drosophila seminal fluid proteins. Mueller JL, et al. Genetics, 2007 Feb. PMID 17110486, Free PMC Article
    5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 53F
    Names
    CG10956-PB
    Spn53F-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17122898..17124237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043088.2 → NP_001036553.1  serpin 53F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3G2, Q4V3Q3
      Conserved Domains (1) summary
      cd00172
      Location:25 → 376
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V3G2 Q4V3G2

    Gene LinkOut

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