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    CCHa1-R CCHamide-1 receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCHa1-Rprovided by FlyBase
    Official Full Name
    CCHamide-1 receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050106
    Locus tag
    Dmel_CG30106
    See related
    AllianceGenome:FB:FBgn0050106
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CCHa1r; CCHa1R; CCHamide-1 R; CCHamide1r; CG14484; CG18192; CG30106; Dmel\CG30106
    Summary
    Enables allatostatin receptor activity and neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Is expressed in adult brain; adult mushroom body; larval VUM motor neurons; neurosecretory neurons; and ventral midline of embryo. Orthologous to human BRS3 (bombesin receptor subtype 3); GRPR (gastrin releasing peptide receptor); and NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCHa1-R in Genome Data Viewer
    Location:
    54D3-54D4; 2-83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17646848..17665068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13534353..13552573, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rhino Neighboring gene Oxpecker Neighboring gene eukaryotic translation initiation factor 3 subunit c Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental emergence of sleep rhythms enables long-term memory in Drosophila. Poe AR, et al. Sci Adv, 2023 Sep 8. PMID 37683005, Free PMC Article
    2. Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain. Li S, et al. PLoS One, 2013. PMID 24098432, Free PMC Article
    3. The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2. Hansen KK, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21110953
    4. The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila. Farhan A, et al. Sci Rep, 2013 Sep 26. PMID 24067446, Free PMC Article
    5. The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster. Fujiwara Y, et al. Front Physiol, 2018. PMID 30246807, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CCHamide-1 receptor is another important factor governing starvation-induced olfactory modifications.
      Title: The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila.
    2. G-protein-coupled receptors coded for by genes CG14593 and CG30106 that are selectively activated by Drosophila CCH-amide-1 and CCH-amide-2, respectively, were cloned.
      Title: The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables allatostatin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables allatostatin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CCHamide-1 receptor
    Names
    ASB-receptor
    CCHa1-R-PA
    CG30106-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17646848..17665068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137397.3 → NP_611241.2  CCHamide-1 receptor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611241.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAX0
      Conserved Domains (2) summary
      pfam00001
      Location:98 → 364
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:88 → 188
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAX0.2 A1ZAX0

    Gene LinkOut

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