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    CG10384 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10384provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034731
    Locus tag
    Dmel_CG10384
    See related
    AllianceGenome:FB:FBgn0034731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg10384; Dmel\CG10384
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10384 in Genome Data Viewer
    Location:
    58E2-58E3; 2-100 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22454741..22472995)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18342246..18360500)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickpocket 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. Walls SM Jr, et al. PLoS Genet, 2013. PMID 24339790, Free PMC Article
    2. Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose. Ji Z, et al. Elife, 2021 Apr 13. PMID 33847264, Free PMC Article
    3. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article
    4. Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics. Croset V, et al. Elife, 2018 Apr 19. PMID 29671739, Free PMC Article
    5. The drosophila melanogaster genome: translation factors and RNA binding proteins. Lasko P. J Cell Biol, 2000 Jul 24. PMID 10908586, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 22465375-22465511 mobile_element_type = transposon:BS{}871

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10384-PD
    CG10384-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22454741..22472995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169783.2 → NP_001163254.2  uncharacterized protein Dmel_CG10384, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163254.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X531, E1JGS5, Q8MSK2, Q9W249
      Conserved Domains (1) summary
      cd02395
      Location:44 → 155
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

    2. NM_137829.3 → NP_611673.3  uncharacterized protein Dmel_CG10384, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611673.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X531, E1JGS5, Q8MSK2, Q9W249
      Conserved Domains (1) summary
      cd02395
      Location:44 → 155
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSK2 Q8MSK2
    Q9W249 Q9W249

    Gene LinkOut

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