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    Sf3b6 Splicing factor 3b subunit 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sf3b6provided by FlyBase
    Official Full Name
    Splicing factor 3b subunit 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035692
    Locus tag
    Dmel_CG13298
    See related
    AllianceGenome:FB:FBgn0035692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg13298; CG13298; Dmel\CG13298; SF3B6
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sf3b6 in Genome Data Viewer
    Location:
    65A8-65A8; 3-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6192124..6193179, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6185224..6186279, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene D19A Neighboring gene uncharacterized protein Neighboring gene Transportin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Border cell polarity and collective migration require the spliceosome component Cactin. Miao G, et al. J Cell Biol, 2022 Jul 4. PMID 35612426, Free PMC Article
    2. Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen. Gao Y, et al. J Genet Genomics, 2019 Jan 20. PMID 30745214
    3. The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing. Stegeman R, et al. J Mol Biol, 2016 Sep 11. PMID 27185460, Free PMC Article
    4. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
    5. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    splicing factor 3b subunit 6
    Names
    CG13298-PA
    Sf3b6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6192124..6193179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139780.3 → NP_648037.1  splicing factor 3b subunit 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648037.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRV7
      UniProtKB/TrEMBL
      A0A1B2AK42
      Related
      FBpp0076723
      Conserved Domains (1) summary
      cd12241
      Location:13 → 89
      RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRV7.1 Q9VRV7

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