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    unc-13-4A unc-13-4A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-13-4Aprovided by FlyBase
    Official Full Name
    unc-13-4Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035756
    Locus tag
    Dmel_CG32381
    See related
    AllianceGenome:FB:FBgn0035756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14831; CG14832; CG14833; CG32381; CG8608; Dmel\CG32381; dunc-13-4A; UNC-13-4A
    Summary
    Predicted to be active in secretory vesicle. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 3. Orthologous to several human genes including BAIAP3 (BAI1 associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc-13-4A in Genome Data Viewer
    Location:
    65E10-65F4; 3-19 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7266192..7312896, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7259292..7305996, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43470 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 4 Neighboring gene uncharacterized protein Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene RAD50 interactor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation. Muñoz-Soriano V, et al. Dev Biol, 2013 May 1. PMID 23428616, Free PMC Article
    2. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article
    3. Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Bergman CM, et al. Genome Biol, 2006. PMID 17134480, Free PMC Article
    4. Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster. Takahara B, et al. PLoS One, 2015. PMID 26182199, Free PMC Article
    5. Vesicle-Mediated Steroid Hormone Secretion in Drosophila melanogaster. Yamanaka N, et al. Cell, 2015 Nov 5. PMID 26544939, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle priming NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in secretory vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unc-13-4A
    Names
    CG32381-PB
    CG32381-PC
    unc-13-4A-PB
    unc-13-4A-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7266192..7312896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274575.2 → NP_001261504.1  unc-13-4A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN63, Q9VS41
      Conserved Domains (3) summary
      cd04009
      Location:1199 → 1330
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:319 → 547
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:1075 → 1179
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    2. NM_139839.5 → NP_648096.4  unc-13-4A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648096.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN63, Q9VS41
      Conserved Domains (3) summary
      cd04009
      Location:1199 → 1330
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:319 → 547
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:1075 → 1179
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS41 Q9VS41

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