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    SMSr Sphingomyelin synthase related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMSrprovided by FlyBase
    Official Full Name
    Sphingomyelin synthase relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052380
    Locus tag
    Dmel_CG32380
    See related
    AllianceGenome:FB:FBgn0052380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32380; CG8572; CG8576; Css3beta; Dmel\CG32380; dmSMSr; dSMSr
    Summary
    Enables ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human SAMD8 (sterile alpha motif domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SMSr in Genome Data Viewer
    Location:
    65F7-65F9; 3-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7374050..7381474, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7367150..7374574, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sh3beta Neighboring gene akirin Neighboring gene smallminded Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The multigenic sphingomyelin synthase family. Tafesse FG, et al. J Biol Chem, 2006 Oct 6. PMID 16905542
    2. Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid. Panevska A, et al. Biochim Biophys Acta Biomembr, 2019 Jul 1. PMID 31067435
    3. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
    4. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. Vacaru AM, et al. J Cell Biol, 2009 Jun 15. PMID 19506037, Free PMC Article
    5. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide cholinephosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingomyelin biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sphingomyelin synthase related
    Names
    CG32380-PA
    CPE synthase
    SMSr-PA
    NP_648114.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7374050..7381474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139857.3 → NP_648114.1  sphingomyelin synthase related [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961G5, Q9VS60, Q9VS61
      Related
      FBpp0076580
      Conserved Domains (2) summary
      cd09515
      Location:55 → 126
      SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
      pfam14360
      Location:349 → 422
      PAP2_C; PAP2 superfamily C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS60.2 Q9VS60

    Gene LinkOut

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