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    CG8563 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8563provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035777
    Locus tag
    Dmel_CG8563
    See related
    AllianceGenome:FB:FBgn0035777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8563
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPA3 (carboxypeptidase A3) and CPB2 (carboxypeptidase B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8563 in Genome Data Viewer
    Location:
    65F10-65F11; 3-20 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7390742..7396013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7383842..7389113)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene smallminded Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance. Nagy S, et al. PLoS Genet, 2018 Dec. PMID 30566533, Free PMC Article
    2. Stonewalling Drosophila stem cell differentiation by epigenetic controls. Maines JZ, et al. Development, 2007 Apr. PMID 17344229
    3. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8563-PA
    CG8563-PB
    NP_001261515.1
    NP_648116.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7390742..7396013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274586.1 → NP_001261515.1  uncharacterized protein Dmel_CG8563, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYY0, Q9VS64
      Conserved Domains (1) summary
      cd03860
      Location:146 → 437
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like

    2. NM_139859.2 → NP_648116.2  uncharacterized protein Dmel_CG8563, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648116.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYY0, Q9VS64
      Related
      FBpp0076562
      Conserved Domains (1) summary
      cd03860
      Location:146 → 437
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYY0 Q8MYY0
    Q9VS64 Q9VS64

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