U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dscam4 Down syndrome cell adhesion molecule 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2769008, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dscam4provided by FlyBase
    Official Full Name
    Down syndrome cell adhesion molecule 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0263219
    Locus tag
    Dmel_CG42330
    See related
    AllianceGenome:FB:FBgn0263219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13672; CG18630; CG33274; CG42330; CG7060; CT21829; Dmel\CG42330; DSCAM
    Old locus tag
    CG13672; Dmel_CG13672; Dmel_CG33274
    Summary
    Predicted to enable cell-cell adhesion mediator activity and identical protein binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and nervous system development. Predicted to be active in axon and plasma membrane. Is expressed in adult head. Orthologous to human DSCAM (DS cell adhesion molecule) and DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dscam4 in Genome Data Viewer
    Location:
    66C1-66C4; 3-24 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8238647..8282398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8231747..8275498)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43953 Neighboring gene eukaryotic translation initiation factor 4E3 Neighboring gene uncharacterized protein Neighboring gene ceramide transfer protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glial Tiling in the Insect Nervous System. Pogodalla N, et al. Front Cell Neurosci, 2022. PMID 35250488, Free PMC Article
    2. The evolution of Dscam genes across the arthropods. Armitage SA, et al. BMC Evol Biol, 2012 Apr 13. PMID 22500922, Free PMC Article
    3. Dscam-mediated cell recognition regulates neural circuit formation. Hattori D, et al. Annu Rev Cell Dev Biol, 2008. PMID 18837673, Free PMC Article
    4. A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development. Funada M, et al. Eur J Neurosci, 2007 Jan. PMID 17241278
    5. Dscam2 mediates axonal tiling in the Drosophila visual system. Millard SS, et al. Nature, 2007 Jun 7. PMID 17554308, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    down syndrome cell adhesion molecule 4
    Names
    CG42330-PD
    CG42330-PE
    CG42330-PH
    CG42330-PI
    CG42330-PJ
    Dscam4-PD
    Dscam4-PE
    Dscam4-PH
    Dscam4-PI
    Dscam4-PJ

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8238647..8282398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144436.2 → NP_001137908.1  down syndrome cell adhesion molecule 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G9
      Conserved Domains (8) summary
      cd00063
      Location:906 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1123 → 1209
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain

    2. NM_001274642.1 → NP_001261571.1  down syndrome cell adhesion molecule 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHS6
      Conserved Domains (8) summary
      cd00063
      Location:906 → 999
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1117 → 1203
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain

    3. NM_001144437.2 → NP_001137909.1  down syndrome cell adhesion molecule 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0D9
      Conserved Domains (8) summary
      cd00096
      Location:439 → 513
      Ig; Immunoglobulin domain
      smart00408
      Location:532 → 594
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:624 → 703
      IG; Immunoglobulin
      smart00410
      Location:429 → 516
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:335 → 416
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:1123 → 1209
      fn3; Fibronectin type III domain
      cl11960
      Location:819 → 909
      Ig; Immunoglobulin domain

    4. NM_001274643.2 → NP_001261572.1  down syndrome cell adhesion molecule 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHS6
      Conserved Domains (8) summary
      cd00063
      Location:906 → 999
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1117 → 1203
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain

    5. NM_001043131.3 → NP_001036596.2  down syndrome cell adhesion molecule 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036596.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G9
      Conserved Domains (8) summary
      cd00063
      Location:906 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1123 → 1209
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0D9 B7Z0D9
    M9PHS6 M9PHS6
    Q0E8G9 Q0E8G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous