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    CG42673 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42673provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261555
    Locus tag
    Dmel_CG42673
    See related
    AllianceGenome:FB:FBgn0261555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE71517; BcDNA:RE71585; CG14178; CG17357; CG3179; CG32048; CG34272; Dmel\CG42673; Dm_3L:44995
    Old locus tag
    Dmel_CG32048; Dmel_CG34272
    Summary
    Predicted to enable nitric-oxide synthase binding activity. Predicted to be involved in postsynaptic actin cytoskeleton organization. Predicted to be located in glutamatergic synapse. Is expressed in several structures, including anal pad primordium; embryonic Malpighian tubule tip cell; epithelium; ganglia; and gut section. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42673 in Genome Data Viewer
    Location:
    67B13-67C1; 3-31 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9547220..9596713)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9540320..9589813)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 67a Neighboring gene Ionotropic receptor 67a Neighboring gene antisense RNA:CR46246 Neighboring gene uncharacterized protein Neighboring gene Transmembrane channel-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. Guzman RM, et al. Genetics, 2021 Mar 31. PMID 33789347, Free PMC Article
    2. Affinity Density: a novel genomic approach to the identification of transcription factor regulatory targets. Hazelett DJ, et al. Bioinformatics, 2009 Jul 1. PMID 19401399, Free PMC Article
    3. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article
    4. Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays. Butler MJ, et al. Development, 2003 Feb. PMID 12505997
    5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nitric-oxide synthase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in postsynaptic actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in glutamatergic synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42673-PB
    CG42673-PC
    CG42673-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9547220..9596713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202149.2 → NP_001189078.1  uncharacterized protein Dmel_CG42673, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRS2
      Conserved Domains (1) summary
      cd01270
      Location:1 → 180
      PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain

    2. NM_168352.2 → NP_729509.1  uncharacterized protein Dmel_CG42673, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729509.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXX4, Q9VT10, Q9VT12
      Related
      FBpp0291849
      Conserved Domains (1) summary
      cd01270
      Location:1 → 180
      PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain

    3. NM_168353.2 → NP_729510.1  uncharacterized protein Dmel_CG42673, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXX4
      Related
      FBpp0291850
      Conserved Domains (1) summary
      cl17171
      Location:352 → 386
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRS2 M9MRS2
    Q8SXX4.1 Q8SXX4

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