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    SCaMC Short Calcium-binding Mitochondrial Carrier [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCaMCprovided by FlyBase
    Official Full Name
    Short Calcium-binding Mitochondrial Carrierprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052103
    Locus tag
    Dmel_CG32103
    See related
    AllianceGenome:FB:FBgn0052103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18022; CG32103; CG4392; Dmel\CG32103
    Summary
    Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in ADP transport and ATP transport. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head; adult heart; gonad; and visceral mesoderm derivative. Orthologous to several human genes including SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SCaMC in Genome Data Viewer
    Location:
    69B4-69B5; 3-38 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12402295..12414842, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12395395..12407942, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 69a Neighboring gene SET and MYND domain containing, class 4, member 2 Neighboring gene ADP-ribosylation factor GTPase activating protein 1 Neighboring gene twin of eyg

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLC30A9: an evolutionarily conserved mitochondrial zinc transporter essential for mammalian early embryonic development. Ge J, et al. Cell Mol Life Sci, 2024 Aug 19. PMID 39158587, Free PMC Article
    2. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
    3. Evolution of Plasticity in Response to Ethanol between Sister Species with Different Ecological Histories (Drosophila melanogaster and D. simulans). Signor SA. Am Nat, 2020 Nov. PMID 33064591
    4. Functional Validation of Candidate Genes Detected by Genomic Feature Models. Rohde PD, et al. G3 (Bethesda), 2018 May 4. PMID 29519937, Free PMC Article
    5. The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. Hofherr A, et al. PLoS Biol, 2018 Aug. PMID 30080851, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short Calcium-binding mitochondrial carrier
    Names
    CG32103-PB
    CG32103-PC
    CG32103-PD
    CG32103-PE
    SCaMC-PB
    SCaMC-PC
    SCaMC-PD
    SCaMC-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12402295..12414842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206345.2 → NP_996067.1  short Calcium-binding mitochondrial carrier, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8F2, Q8MR46
      Conserved Domains (3) summary
      COG5126
      Location:100 → 247
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:186 → 242
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:375 → 463
      Mito_carr; Mitochondrial carrier protein

    2. NM_168498.1 → NP_729802.1  short Calcium-binding mitochondrial carrier, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8F2, Q8MR46
      Related
      FBpp0075714, FBtr0075982
      Conserved Domains (3) summary
      COG5126
      Location:100 → 247
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:186 → 242
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:375 → 463
      Mito_carr; Mitochondrial carrier protein

    3. NM_168499.2 → NP_729803.1  short Calcium-binding mitochondrial carrier, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTX3
      Related
      FBpp0075715
      Conserved Domains (1) summary
      PTZ00169
      Location:70 → 339
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    4. NM_001274831.1 → NP_001261760.1  short Calcium-binding mitochondrial carrier, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF04
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 230
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF04 M9PF04
    Q0E8F2 Q0E8F2
    Q8MR46 Q8MR46
    Q9VTX3 Q9VTX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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