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    endos endosulfine [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    endosprovided by FlyBase
    Official Full Name
    endosulfineprovided by FlyBase
    Primary source
    FLYBASE:FBgn0061515
    Locus tag
    Dmel_CG6513
    See related
    AllianceGenome:FB:FBgn0061515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0670/06; CG6513; dendos; Dmel\CG6513; End; Endos; ENSA; l(3)S067006
    Summary
    Enables protein phosphatase inhibitor activity. Involved in several processes, including regulation of meiotic cell cycle; regulation of mitotic nuclear division; and response to nutrient. Predicted to be active in cytoplasm. Is expressed in Malpighian tubule; adult head; embryonic/larval proventriculus; and larval brain. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19) and ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See endos in Genome Data Viewer
    Location:
    70C14-70C15; 3-41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14029579..14031706, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14022679..14024806, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene upSET Neighboring gene PAX transcription activation domain interacting protein Neighboring gene antisense RNA:CR42871 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alpha-endosulfine, a potential regulator of insulin secretion, is required for adult tissue growth control in Drosophila. Drummond-Barbosa D, et al. Dev Biol, 2004 Feb 15. PMID 14738879
    2. Greatwall-Endos-PP2A/B55(Twins) network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition. Rangone H, et al. Open Biol, 2024 Jun. PMID 38896085, Free PMC Article
    3. A Genetic Screen for Dominant Enhancers of the Cell-Cycle Regulator α-Endosulfine Identifies Matrimony as a Strong Functional Interactor in Drosophila. Von Stetina JR, et al. G3 (Bethesda), 2011 Dec. PMID 22384372, Free PMC Article
    4. Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle. Wang P, et al. Cell Cycle, 2016. PMID 26761639, Free PMC Article
    5. Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression. Larouche M, et al. J Cell Biol, 2021 Jun 7. PMID 33836042, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Greatwall-Endos-PP2A/B55[Twins] network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.
      Title: Greatwall-Endos-PP2A/B55(Twins) network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.
    2. This mechanism explains simultaneously how PP2A-B55 and Gwl together regulate phosphorylated Endos, and how phosphorylated Endos controls PP2A-B55.
      Title: Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.
    3. Greatwall phosphorylates Endos at a single site, Ser68, and this is essential for Endos function
      Title: Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis.
    4. Endos controls meiotic maturation by regulating Twine and Polo levels, and, independently, by antagonizing Elgi
      Title: alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila.
    5. Data suggest that the Drosophila alpha-endosulfine (dendos) gene is required for the proliferative response of ovarian cells to nutritional changes.
      Title: Alpha-endosulfine, a potential regulator of insulin secretion, is required for adult tissue growth control in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endosulfine
    Names
    CG6513-PA
    CG6513-PB
    CG6513-PC
    CG6513-PD
    CG6513-PE
    CG6513-PF
    alpha-endosulfine
    dendos
    endos-PA
    endos-PB
    endos-PC
    endos-PD
    endos-PE
    endos-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14029579..14031706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274891.1 → NP_001261820.1  endosulfine, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB8
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 117
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    2. NM_140427.3 → NP_648684.1  endosulfine, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB8
      Related
      FBpp0099872
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 117
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    3. NM_001274892.1 → NP_001261821.1  endosulfine, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB8
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 117
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    4. NM_001259816.2 → NP_001246745.1  endosulfine, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB8
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 117
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    5. NM_001259817.2 → NP_001246746.1  endosulfine, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB8
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 117
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    6. NM_168572.2 → NP_729949.1  endosulfine, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB8
      Related
      FBpp0099873
      Conserved Domains (1) summary
      pfam04667
      Location:33 → 117
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUB8 Q9VUB8

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