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    CG18223 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40068, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18223provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036832
    Locus tag
    Dmel_CG18223
    See related
    AllianceGenome:FB:FBgn0036832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT03311; Dmel\CG18223; SPH200
    Summary
    Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18223 in Genome Data Viewer
    Location:
    75E6-75E6; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18919224..18920319, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18912324..18913419, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 1b Neighboring gene pre-mRNA processing factor 6 Neighboring gene Cytochrome c oxidase subunit 6A-like 2 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
    2. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article
    3. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    4. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848
    5. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18223-PA
    CG18223-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18919224..18920319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140820.2 → NP_649077.1  uncharacterized protein Dmel_CG18223, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVV0
      Related
      FBpp0074838
      Conserved Domains (2) summary
      smart00020
      Location:60 → 280
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:60 → 283
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001275097.2 → NP_001262026.1  uncharacterized protein Dmel_CG18223, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4I7
      Conserved Domains (1) summary
      cl21584
      Location:60 → 95
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4I7 Q8T4I7
    Q9VVV0 Q9VVV0

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