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    CG8500 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8500provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037754
    Locus tag
    Dmel_CG8500
    See related
    AllianceGenome:FB:FBgn0037754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8500; Q9VH66
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including DIRAS2 (DIRAS family GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8500 in Genome Data Viewer
    Location:
    85E9-85E9; 3-49 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9784653..9789323)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5610375..5615045)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR31514 Neighboring gene uncharacterized protein Neighboring gene Metallothionein A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46144 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of mTORC1 by the Rab and Arf GTPases. Li L, et al. J Biol Chem, 2010 Jun 25. PMID 20457610, Free PMC Article
    2. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
    3. Human RAS superfamily proteins and related GTPases. Colicelli J. Sci STKE, 2004 Sep 7. PMID 15367757, Free PMC Article
    4. Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase. Page AR, et al. EMBO J, 2005 Dec 21. PMID 16369566, Free PMC Article
    5. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8500-PA
    CG8500-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9784653..9789323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141691.2 → NP_649948.1  uncharacterized protein Dmel_CG8500, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH66
      Related
      FBpp0081617
      Conserved Domains (1) summary
      cd04140
      Location:18 → 183
      ARHI_like; A Ras homolog member I (ARHI)

    2. NM_001316523.1 → NP_001303452.1  uncharacterized protein Dmel_CG8500, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH66
      Conserved Domains (1) summary
      cd04140
      Location:18 → 183
      ARHI_like; A Ras homolog member I (ARHI)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH66 Q9VH66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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