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    CG5342 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5342provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037916
    Locus tag
    Dmel_CG5342
    See related
    AllianceGenome:FB:FBgn0037916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5342
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5342 in Genome Data Viewer
    Location:
    86E11-86E11; 3-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11578826..11581476)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7404548..7407198)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein Neighboring gene scheggia Neighboring gene Multidrug resistance protein 4 Neighboring gene uncharacterized protein Neighboring gene whacked Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Jupiter, a new Drosophila protein associated with microtubules. Karpova N, et al. Cell Motil Cytoskeleton, 2006 May. PMID 16518797
    2. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
    3. Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Kankel MW, et al. Genetics, 2020 Jul. PMID 32345615, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5342-PB
    NP_650088.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11578826..11581476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141831.2 → NP_650088.2  uncharacterized protein Dmel_CG5342 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650088.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E6F9, Q9VGL9
      Conserved Domains (2) summary
      pfam04987
      Location:398 → 781
      PigN; Phosphatidylinositolglycan class N (PIG-N)
      cd16020
      Location:43 → 318
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGL9 Q9VGL9

    Gene LinkOut

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