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    CG14721 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14721provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037942
    Locus tag
    Dmel_CG14721
    See related
    AllianceGenome:FB:FBgn0037942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14721
    Summary
    Predicted to enable thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14721 in Genome Data Viewer
    Location:
    86E17-86E17; 3-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11735447..11736877)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7561169..7562599)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bloom syndrome helicase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
    2. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article
    3. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thiamine diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14721-PA
    CG14721-PB
    NP_001262483.1
    NP_650110.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11735447..11736877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141853.3 → NP_650110.3  uncharacterized protein Dmel_CG14721, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650110.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4A5, Q9VGI9
      Related
      FBpp0081906
      Conserved Domains (2) summary
      cd07995
      Location:100 → 328
      TPK; Thiamine pyrophosphokinase
      TIGR01378
      Location:101 → 330
      thi_PPkinase; thiamine pyrophosphokinase

    2. NM_001275554.1 → NP_001262483.1  uncharacterized protein Dmel_CG14721, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFS3
      Conserved Domains (2) summary
      cd07995
      Location:30 → 258
      TPK; Thiamine pyrophosphokinase
      TIGR01378
      Location:31 → 260
      thi_PPkinase; thiamine pyrophosphokinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFS3 A0A0B4KFS3
    Q8T4A5 Q8T4A5

    Gene LinkOut

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