GC1 Glutamate Carrier 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GC1provided by FlyBase
Official Full Name: Glutamate Carrier 1provided by FlyBase
Primary source: FLYBASE:FBgn0260743
Locus tag: Dmel_CG18347
See related: AllianceGenome:FB:FBgn0260743
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 87A7-9/4; anon-87Ac; CG18347; Dmel\CG18347; DmGC1
Summary: Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including adult Malpighian tubule; anterior-posterior subdivision of organism; and gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to several human genes including SLC25A22 (solute carrier family 25 member 22). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11967708..11971686)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7793430..7797408)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables high-affinity L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate-aspartate shuttle	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain