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    CG6974 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6974provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038285
    Locus tag
    Dmel_CG6974
    See related
    AllianceGenome:FB:FBgn0038285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6974
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6974 in Genome Data Viewer
    Location:
    88E1-88E1; 3-56 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15078530..15079285, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10904252..10905007, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44944 Neighboring gene defective proboscis extension response 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2493 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New levels of transcriptome complexity at upper thermal limits in wild Drosophila revealed by exon expression analysis. Telonis-Scott M, et al. Genetics, 2013 Nov. PMID 24002645, Free PMC Article
    2. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    3. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    4. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6974-PA
    NP_650414.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15078530..15079285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142157.1 → NP_650414.1  uncharacterized protein Dmel_CG6974 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFD6
      Related
      FBpp0082501, FBtr0083042
      Conserved Domains (2) summary
      cd04280
      Location:59 → 249
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:55 → 251
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFD6 Q9VFD6

    Gene LinkOut

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