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    Tmlh Trimethyllysine hydroxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmlhprovided by FlyBase
    Official Full Name
    Trimethyllysine hydroxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038795
    Locus tag
    Dmel_CG4335
    See related
    AllianceGenome:FB:FBgn0038795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4335; Dmel\CG4335; TMLH; TMLHE
    Summary
    Predicted to enable trimethyllysine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TMLHE (trimethyllysine hydroxylase, epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmlh in Genome Data Viewer
    Location:
    92E7-92E7; 3-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20406615..20407871, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16232337..16233593, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45023 Neighboring gene Metallothionein C Neighboring gene Glial cell line-derived neurotrophic family receptor-like Neighboring gene eukaryotic translation initiation factor 3 subunit g2 Neighboring gene long non-coding RNA:CR44400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII. Kallijärvi J, et al. PLoS One, 2012. PMID 23284846, Free PMC Article
    2. Oncogenic stress-induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila. Okada M, et al. EMBO J, 2023 Jun 15. PMID 37140455, Free PMC Article
    3. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
    4. A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Egli D, et al. Mol Cell Biol, 2006 Mar. PMID 16508004, Free PMC Article
    5. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trimethyllysine dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trimethyllysine dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnitine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    trimethyllysine hydroxylase
    Names
    CG4335-PA
    TML hydroxylase
    Tmlh-PA
    NP_650886.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20406615..20407871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142629.4 → NP_650886.1  trimethyllysine hydroxylase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6C2, Q9VDM7
      Related
      FBpp0083302
      Conserved Domains (3) summary
      TIGR02410
      Location:19 → 361
      carnitine_TMLD; trimethyllysine dioxygenase
      cl00184
      Location:110 → 350
      CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
      cl01414
      Location:19 → 70
      DUF971; Protein of unknown function (DUF971)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDM7 Q9VDM7

    Gene LinkOut

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