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    TBC1d7 TBC1 domain family member 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TBC1d7provided by FlyBase
    Official Full Name
    TBC1 domain family member 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0039158
    Locus tag
    Dmel_CG6182
    See related
    AllianceGenome:FB:FBgn0039158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD17019; CG6182; Dmel\CG6182; dTBC1D7; TBC1D7
    Summary
    Enables TSC1-TSC2 complex binding activity. Involved in glucose homeostasis and negative regulation of insulin secretion. Predicted to be part of TSC1-TSC2 complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human TBC1D7 (TBC1 domain family member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TBC1d7 in Genome Data Viewer
    Location:
    95E6-95E6; 3-83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24161727..24163215)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19987449..19988937)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p38a MAP kinase Neighboring gene uncharacterized protein Neighboring gene Myosin 95E Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. Ren S, et al. J Cell Biol, 2018 Feb 5. PMID 29187524, Free PMC Article
    2. Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth. Frappaolo A, et al. Cells, 2023 Nov 14. PMID 37998357, Free PMC Article
    3. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    4. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Housden BE, et al. Sci Signal, 2015 Sep 8. PMID 26350902, Free PMC Article
    5. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables TSC1-TSC2 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TSC1-TSC2 complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 7
    Names
    CG6182-PA
    TBC1d7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24161727..24163215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142966.3 → NP_651223.2  TBC1 domain family member 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651223.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUZ0, Q9VCC4
      Related
      FBpp0083936
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JUZ0 Q7JUZ0
    Q9VCC4 Q9VCC4

    Gene LinkOut

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