U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    side sidestep [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43300, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sideprovided by FlyBase
    Official Full Name
    sidestepprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016061
    Locus tag
    Dmel_CG31062
    See related
    AllianceGenome:FB:FBgn0016061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12510; CG13973; CG13974; CG13975; CG13979; CG31062; CT33527; CT33528; Dmel\CG31062; doe; Doe; Side
    Summary
    Involved in motor neuron axon guidance. Is expressed in adult head; larval central nervous system; larval muscle system; lobula columnar neuron LC14; and midline. Orthologous to human VSIG10L (V-set and immunoglobulin domain containing 10 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See side in Genome Data Viewer
    Location:
    97F6-98A1; 3-93 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27375088..27437482, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23200810..23263204, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43476 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45991 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Misregulation of Drosophila Sidestep Leads to Uncontrolled Wiring of the Adult Neuromuscular System and Severe Locomotion Defects. Kinold JC, et al. Front Neural Circuits, 2021. PMID 34149366, Free PMC Article
    2. The Drosophila cell adhesion molecule Neuroglian regulates Lissencephaly-1 localisation in circulating immunosurveillance cells. Williams MJ. BMC Immunol, 2009 Mar 25. PMID 19320973, Free PMC Article
    3. sidestep encodes a target-derived attractant essential for motor axon guidance in Drosophila. Sink H, et al. Cell, 2001 Apr 6. PMID 11301002
    4. Molecular insights into the axon guidance molecules Sidestep and Beaten path. Heymann C, et al. Front Physiol, 2022. PMID 36518105, Free PMC Article
    5. Drosophila motor axons recognize and follow a Sidestep-labeled substrate pathway to reach their target fields. Siebert M, et al. Genes Dev, 2009 May 1. PMID 19369411, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. guidance errors in sidestep mutants are maintained throughout larval life and are asymmetrical with respect to the bilateral body axis.
      Title: Sidestep-induced neuromuscular miswiring causes severe locomotion defects in Drosophila larvae.
    2. motor axons recognize and follow Side-expressing cell surfaces from the ventral nerve cord to their target region
      Title: Drosophila motor axons recognize and follow a Sidestep-labeled substrate pathway to reach their target fields.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sidestep
    Names
    CG31062-PA
    CG31062-PB
    CG31062-PC
    CG31062-PD
    downstream of eyeless
    side-PA
    side-PB
    side-PC
    side-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27375088..27437482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144645.3 → NP_001138117.1  sidestep, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R1, Q967X6
      Conserved Domains (5) summary
      smart00410
      Location:435 → 511
      IG_like; Immunoglobulin like
      cd00063
      Location:700 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07686
      Location:95 → 211
      V-set; Immunoglobulin V-set domain
      pfam13895
      Location:442 → 511
      Ig_2; Immunoglobulin domain
      cl11960
      Location:326 → 408
      Ig; Immunoglobulin domain

    2. NM_001260406.2 → NP_001247335.1  sidestep, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6K0, Q967X6
      Conserved Domains (5) summary
      smart00410
      Location:435 → 511
      IG_like; Immunoglobulin like
      cd00063
      Location:700 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07686
      Location:95 → 211
      V-set; Immunoglobulin V-set domain
      pfam13895
      Location:442 → 511
      Ig_2; Immunoglobulin domain
      cl11960
      Location:326 → 408
      Ig; Immunoglobulin domain

    3. NM_001260405.2 → NP_001247334.1  sidestep, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7N1, Q967X6
      Conserved Domains (5) summary
      smart00410
      Location:435 → 511
      IG_like; Immunoglobulin like
      cd00063
      Location:700 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07686
      Location:95 → 211
      V-set; Immunoglobulin V-set domain
      pfam13895
      Location:442 → 511
      Ig_2; Immunoglobulin domain
      cl11960
      Location:326 → 408
      Ig; Immunoglobulin domain

    4. NM_079806.4 → NP_524530.2  sidestep, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524530.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q967X6, Q9VB35
      Related
      FBpp0084538
      Conserved Domains (5) summary
      smart00410
      Location:435 → 511
      IG_like; Immunoglobulin like
      cd00063
      Location:700 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07686
      Location:95 → 211
      V-set; Immunoglobulin V-set domain
      pfam13895
      Location:442 → 511
      Ig_2; Immunoglobulin domain
      cl11960
      Location:326 → 408
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6K0 A0A0B4K6K0
    A0A0B4K7N1 A0A0B4K7N1
    B7Z0R1 B7Z0R1
    Q967X6 Q967X6
    Q9VB35 Q9VB35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools