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    Nph Nucleophosmin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nphprovided by FlyBase
    Official Full Name
    Nucleophosminprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039735
    Locus tag
    Dmel_CG7911
    See related
    AllianceGenome:FB:FBgn0039735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7911; Dmel\CG7911; NPH
    Summary
    Enables histone binding activity. Involved in chromatin remodeling and sperm DNA decondensation. Located in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including NPM2 (nucleophosmin/nucleoplasmin 2) and NPM3 (nucleophosmin/nucleoplasmin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nph in Genome Data Viewer
    Location:
    99D1-99D1; 3-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30003681..30004861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25829403..25830583, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tace Neighboring gene Nucleoplasmin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization. Anselm E, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30357352, Free PMC Article
    2. Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin. Emelyanov AV, et al. Genes Dev, 2016 Dec 15. PMID 28031247, Free PMC Article
    3. Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles. Lacroix E, et al. Front Mol Biosci, 2022. PMID 36203874, Free PMC Article
    4. New Functional Motifs for the Targeted Localization of Proteins to the Nucleolus in Drosophila and Human Cells. Ogienko AA, et al. Int J Mol Sci, 2024 Jan 19. PMID 38279227, Free PMC Article
    5. The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila. Lukacs A, et al. PLoS Genet, 2021 Aug. PMID 34424906, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm DNA decondensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleophosmin
    Names
    CG7911-PA
    CG7911-PB
    Nph-PA
    Nph-PB
    nucleoplasmin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30003681..30004861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143503.2 → NP_651760.1  nucleophosmin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAC4
      Related
      FBpp0084971
      Conserved Domains (1) summary
      pfam03066
      Location:6 → 112
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

    2. NM_001104505.2 → NP_001097975.1  nucleophosmin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAC4
      Conserved Domains (1) summary
      pfam03066
      Location:6 → 112
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAC4 Q9VAC4

    Gene LinkOut

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