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    CG9733 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9733provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039759
    Locus tag
    Dmel_CG9733
    See related
    AllianceGenome:FB:FBgn0039759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP10; cSP10; Dmel\CG9733; proAE; proPO-AE; SP10
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9733 in Genome Data Viewer
    Location:
    99E3-99E3; 3-100 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30243978..30246703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26069700..26072425, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Leucine-TAG 1-1 Neighboring gene transfer RNA:Leucine-TAG 1-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and regulation of Spätzle-processing enzyme in Drosophila. Mulinari S, et al. FEBS Lett, 2006 Oct 2. PMID 16996061
    2. Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. Marshall KE, et al. Proc Biol Sci, 2010 Mar 22. PMID 19939842, Free PMC Article
    3. Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster. Winterhalter WE, et al. Proc Biol Sci, 2009 Mar 22. PMID 19129115, Free PMC Article
    4. A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Jang IH, et al. Dev Cell, 2006 Jan. PMID 16399077
    5. Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging. Rai M, et al. Cell Metab, 2021 Jun 1. PMID 33773104, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9733-PA
    CG9733-PB
    POAE-like serine protease
    pro-phenoloxidase AE
    NP_001287606.1
    NP_651784.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30243978..30246703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300677.1 → NP_001287606.1  uncharacterized protein Dmel_CG9733, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHW2, Q8SZK2
      Conserved Domains (3) summary
      smart00020
      Location:160 → 411
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:161 → 414
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:24 → 77
      CLIP; Regulatory CLIP domain of proteinases

    2. NM_143527.3 → NP_651784.2  uncharacterized protein Dmel_CG9733, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651784.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZK2, Q9VA87
      Related
      FBpp0085000
      Conserved Domains (3) summary
      smart00020
      Location:161 → 412
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:162 → 415
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:25 → 78
      CLIP; Regulatory CLIP domain of proteinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHW2 A0A0B4LHW2
    Q8SZK2 Q8SZK2
    Q9VA87 Q9VA87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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