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    Ekar Eye-enriched kainate receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ekarprovided by FlyBase
    Official Full Name
    Eye-enriched kainate receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039916
    Locus tag
    Dmel_CG9935
    See related
    AllianceGenome:FB:FBgn0039916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9935; CT36399; DmelCG9935; Dmel\CG9935; ekar
    Summary
    Predicted to enable kainate selective glutamate receptor activity. Involved in several processes, including glutamatergic synaptic transmission; optomotor response; and regulation of membrane potential in photoreceptor cell. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult head; eye; and photoreceptor neurons. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive intellectual developmental disorder 6; childhood absence epilepsy; and chronic obstructive pulmonary disease. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1); GRIK2 (glutamate ionotropic receptor kainate type subunit 2); and GRIK3 (glutamate ionotropic receptor kainate type subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ekar in Genome Data Viewer
    Location:
    102D1-102D1; 4-0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (636131..646556, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (656757..667182, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene mir-954 stem loop Neighboring gene GABA transporter Neighboring gene pseudo Neighboring gene gawky Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of a distinct genomic domain in Drosophila: comparative analysis of the dot chromosome in Drosophila melanogaster and Drosophila virilis. Leung W, et al. Genetics, 2010 Aug. PMID 20479145, Free PMC Article
    2. Gcm counteracts Toll-induced inflammation and impacts hemocyte number through cholinergic signaling. Bazzi W, et al. Front Immunol, 2023. PMID 38035083, Free PMC Article
    3. A Screen for Synaptic Growth Mutants Reveals Mechanisms That Stabilize Synaptic Strength. Goel P, et al. J Neurosci, 2019 May 22. PMID 30902873, Free PMC Article
    4. Novel Functional Properties of Drosophila CNS Glutamate Receptors. Li Y, et al. Neuron, 2016 Dec 7. PMID 27889096, Free PMC Article
    5. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Karuppudurai T, et al. Neuron, 2014 Feb 5. PMID 24507194, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c638430-638329 mobile_element_type = transposon:INE-1{}1926
    • Loc: c641154-640788 mobile_element_type = transposon:INE-1{}1927
    • Loc: c641498-641408 mobile_element_type = transposon:INE-1{}1929
    • Loc: c643106-642959 mobile_element_type = transposon:INE-1{}1935
    • Loc: c644254-644201 mobile_element_type = transposon:INE-1{}1938
    • Loc: c645548-645198 mobile_element_type = transposon:INE-1{}1939

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to light intensity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in optomotor response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential in photoreceptor cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of membrane potential in photoreceptor cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Eye-enriched kainate receptor
    Names
    CG9935-PA
    CG9935-PB
    CG9935-PD
    Ekar-PA
    Ekar-PB
    Ekar-PD
    eye-enriched kainate receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      636131..646556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042786.2 → NP_001036251.2  Eye-enriched kainate receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036251.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GQ97
      Conserved Domains (4) summary
      cd06382
      Location:24 → 388
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:402 → 770
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:532 → 806
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39 → 371
      ANF_receptor; Receptor family ligand binding region

    2. NM_001042785.2 → NP_001036250.1  Eye-enriched kainate receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036250.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIF2
      Conserved Domains (4) summary
      cd06382
      Location:24 → 388
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:402 → 771
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:533 → 807
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39 → 371
      ANF_receptor; Receptor family ligand binding region

    3. NM_143674.2 → NP_651931.1  Eye-enriched kainate receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDJ4, Q9V4E9
      Related
      FBpp0088171
      Conserved Domains (3) summary
      cd06382
      Location:24 → 388
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      pfam01094
      Location:39 → 371
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:402 → 666
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GQ97 A0A023GQ97
    Q0KIF2 Q0KIF2
    Q8MQM7 Q8MQM7
    Q9V4E9 Q9V4E9

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