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    CG11360 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11360provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039920
    Locus tag
    Dmel_CG11360
    See related
    AllianceGenome:FB:FBgn0039920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg11360; Dmel\CG11360
    Summary
    Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Orthologous to several human genes including MEX3B (mex-3 RNA binding family member B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11360 in Genome Data Viewer
    Location:
    102D4-102D4; 4-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (671142..690650)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (691768..711276)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SLo interacting protein 1 Neighboring gene myoglianin Neighboring gene eyeless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global patterns of tissue-specific alternative polyadenylation in Drosophila. Smibert P, et al. Cell Rep, 2012 Mar 29. PMID 22685694, Free PMC Article
    2. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. Mohr SE, et al. G3 (Bethesda), 2015 Jul 21. PMID 26199285, Free PMC Article
    3. High-resolution mapping of the Drosophila fourth chromosome using site-directed terminal deficiencies. Sousa-Neves R, et al. Genetics, 2005 May. PMID 15466427, Free PMC Article
    4. Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain. Riddle NC, et al. PLoS Genet, 2012 Sep. PMID 23028361, Free PMC Article
    5. Identification of alternative splicing regulators by RNA interference in Drosophila. Park JW, et al. Proc Natl Acad Sci U S A, 2004 Nov 9. PMID 15492211, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 681315-681389 mobile_element_type = transposon:INE-1{}1953
    • Loc: 681512-683872 mobile_element_type = transposon:INE-1{}5389
    • Loc: 681591-682171 mobile_element_type = transposon:1360{}1577

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11360-PA
    CG11360-PC
    CG11360-PD
    CG11360-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      671142..690650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272139.1 → NP_001259068.1  uncharacterized protein Dmel_CG11360, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5T0, Q9V4F3
      Conserved Domains (3) summary
      smart00322
      Location:233 → 298
      KH; K homology RNA-binding domain
      cd00105
      Location:124 → 185
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:575 → 620
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_001272141.1 → NP_001259070.1  uncharacterized protein Dmel_CG11360, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5T0, Q9V4F3
      Conserved Domains (3) summary
      smart00322
      Location:233 → 298
      KH; K homology RNA-binding domain
      cd00105
      Location:124 → 185
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:575 → 620
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    3. NM_001272140.1 → NP_001259069.1  uncharacterized protein Dmel_CG11360, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5T0, Q9V4F3
      Conserved Domains (3) summary
      smart00322
      Location:233 → 298
      KH; K homology RNA-binding domain
      cd00105
      Location:124 → 185
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:575 → 620
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    4. NM_143677.4 → NP_651934.2  uncharacterized protein Dmel_CG11360, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651934.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5T0, Q9V4F3
      Conserved Domains (3) summary
      smart00322
      Location:233 → 298
      KH; K homology RNA-binding domain
      cd00105
      Location:124 → 185
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam13920
      Location:575 → 620
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4F3 Q9V4F3

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