Gyf Gigyf [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gyfprovided by FlyBase
Official Full Name: Gigyfprovided by FlyBase
Primary source: FLYBASE:FBgn0039936
Locus tag: Dmel_CG11148
See related: AllianceGenome:FB:FBgn0039936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11148; Dmel\CG11148; GIGYF2
Summary: Enables mRNA regulatory element binding translation repressor activity. Involved in muscle cell cellular homeostasis; neuron cellular homeostasis; and regulation of autophagy. Part of eukaryotic translation initiation factor 4F complex. Is expressed in organism and ovary. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 102E5-102E5; 4-0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (853557..867025, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (874342..887651, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When in complex with 4EHP, GIGYF not only elicits translational repression but also promotes target mRNA decay via the recruitment of additional effector proteins. GIGYF proteins additionally recruit decapping and deadenylation complexes to 4EHP-containing RNPs to induce translational repression and degradation of mRNA targets.
Title: Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression.
CG11148 is known as GYF; its product is orthologous to GIGYF1 (GRB10-interacting GYF protein 1) and GIGYF2 in mammals, and it is a new autophagy regulator
Title: Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c854279-854185 mobile_element_type = transposon:1360{}2818
Loc: c857387-857231 mobile_element_type = transposon:INE-1{}5412
Loc: c860249-860109 mobile_element_type = transposon:INE-1{}2711

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mRNA regulatory element binding translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: gigyf

Names: CG11148-PD; CG11148-PF; CG11148-PG; CG11148-PH; Gyf-PD; Gyf-PF; Gyf-PG; Gyf-PH

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

853557..867025 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169357.4 → NP_001162828.1 gigyf, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162828.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A422, D1YSG2, E8NH20, Q7KQM6, Q961G4, Q9V482

Conserved Domains (2) summary

cd00072
Location:566 → 621

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

pfam12474
Location:998 → 1112

PKK; Polo kinase kinase
NM_143693.4 → NP_651950.3 gigyf, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651950.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KQM6

Conserved Domains (2) summary

cd00072
Location:559 → 614

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

pfam12474
Location:991 → 1105

PKK; Polo kinase kinase
NM_205878.3 → NP_995600.2 gigyf, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995600.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KQM6

Conserved Domains (2) summary

cd00072
Location:559 → 614

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

pfam12474
Location:991 → 1105

PKK; Polo kinase kinase
NM_001169356.2 → NP_001162827.1 gigyf, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162827.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A422, D1YSG2, E8NH20, Q7KQM6, Q961G4, Q9V482

Conserved Domains (2) summary

cd00072
Location:566 → 621

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

pfam12474
Location:998 → 1112

PKK; Polo kinase kinase