U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG42540 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38562, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG42540provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260657
    Locus tag
    Dmel_CG42540
    See related
    AllianceGenome:FB:FBgn0260657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13718; CG13719; CG32245; CG7468; Dmel\CG42540
    Old locus tag
    Dmel_CG13719; Dmel_CG32245
    Summary
    Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human STOM (stomatin) and STOML3 (stomatin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG42540 in Genome Data Viewer
    Location:
    64B10-64B11; 3-12 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4556087..4592295)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4556087..4592295)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Src oncogene at 64B Neighboring gene long non-coding RNA:CR45438 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior. He X, et al. Genes Brain Behav, 2016 Feb. PMID 26678546, Free PMC Article
    2. Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy. Min Y, et al. Nat Commun, 2023 Nov 2. PMID 37919278, Free PMC Article
    3. Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo. Nil Z, et al. Cell, 2019 Sep 5. PMID 31491385
    4. RNA editing in Drosophila melanogaster: New targets and functional consequences. Stapleton M, et al. RNA, 2006 Nov. PMID 17018572, Free PMC Article
    5. The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology. Rounds JC, et al. Genetics, 2022 Jan 4. PMID 34791182, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG42540-PB
    CG42540-PC
    CG42540-PD
    CG42540-PF
    CG42540-PG
    CG42540-PH
    CG42540-PI
    CG42540-PJ
    CG42540-PK

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4556087..4592295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168095.3 → NP_729016.2  uncharacterized protein Dmel_CG42540, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729016.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZA4
      Conserved Domains (2) summary
      COG0330
      Location:70 → 321
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:110 → 311
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_144080.3 → NP_652337.2  uncharacterized protein Dmel_CG42540, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652337.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZA5
      Conserved Domains (2) summary
      COG0330
      Location:177 → 429
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:218 → 419
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. NM_001274491.1 → NP_001261420.1  uncharacterized protein Dmel_CG42540, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEB7
      Conserved Domains (2) summary
      COG0330
      Location:81 → 332
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:121 → 322
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    4. NM_139660.5 → NP_647917.3  uncharacterized protein Dmel_CG42540, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647917.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZA4
      Conserved Domains (2) summary
      COG0330
      Location:69 → 320
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cl19107
      Location:109 → 310
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    5. NM_001274492.1 → NP_001261421.1  uncharacterized protein Dmel_CG42540, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHF2
      Conserved Domains (2) summary
      COG0330
      Location:173 → 424
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:213 → 414
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    6. NM_001300007.1 → NP_001286936.1  uncharacterized protein Dmel_CG42540, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286936.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC20
      Conserved Domains (2) summary
      COG0330
      Location:77 → 328
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:117 → 318
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    7. NM_001274490.1 → NP_001261419.1  uncharacterized protein Dmel_CG42540, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEM4
      Conserved Domains (2) summary
      COG0330
      Location:65 → 316
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cl19107
      Location:105 → 306
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    8. NM_001259698.1 → NP_001246627.1  uncharacterized protein Dmel_CG42540, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF13
      Conserved Domains (2) summary
      COG0330
      Location:188 → 440
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:229 → 430
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    9. NM_168096.3 → NP_729018.1  uncharacterized protein Dmel_CG42540, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BI93, Q8IRA9, Q8T0L0, Q95SR9, Q9VZA3, Q9VZA4
      UniProtKB/TrEMBL
      H8F4R7
      Related
      FBpp0290317
      Conserved Domains (2) summary
      COG0330
      Location:176 → 428
      HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
      cd03403
      Location:217 → 418
      SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NF13 M9NF13
    M9PEB7 M9PEB7
    M9PEM4 M9PEM4
    M9PHF2 M9PHF2
    Q9VZA4.2 Q9VZA4
    Q9VZA5 Q9VZA5
    X2JC20 X2JC20

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous