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    dpr12 defective proboscis extension response 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpr12provided by FlyBase
    Official Full Name
    defective proboscis extension response 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0085414
    Locus tag
    Dmel_CG34385
    See related
    AllianceGenome:FB:FBgn0085414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14469; CG34385; CG7796; CT34165; Dmel\CG34385; Dpr-12; Dpr12
    Old locus tag
    CG14469; CG7796; Dmel_CG14469; Dmel_CG7796
    Summary
    Involved in synapse organization and synaptic target recognition. Predicted to be active in neuron projection membrane. Is expressed in embryonic head sensory system; larval ventral nerve cord; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpr12 in Genome Data Viewer
    Location:
    42A1-42A1; 2-55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5804712..5860831)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1692217..1748336)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42A Neighboring gene Odorant receptor 42b Neighboring gene long non-coding RNA:CR44125 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal Control of Neuronal Remodeling by Cell Adhesion Molecules: Insights From Drosophila. Meltzer H, et al. Front Neurosci, 2022. PMID 35645712, Free PMC Article
    2. Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules. Xu S, et al. Cell Rep, 2022 Apr 5. PMID 35385751, Free PMC Article
    3. Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Bornstein B, et al. EMBO J, 2021 Jun 15. PMID 33847376, Free PMC Article
    4. Coordination between stochastic and deterministic specification in the Drosophila visual system. Courgeon M, et al. Science, 2019 Oct 18. PMID 31582524, Free PMC Article
    5. Classifying Protein-Protein Binding Affinity with Free-Energy Calculations and Machine Learning Approaches. Goulard Coderc de Lacam E, et al. J Chem Inf Model, 2024 Feb 12. PMID 38272021

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transneuronal Dpr12/DIP-delta interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons.
      Title: Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    defective proboscis extension response 12
    Names
    CG34385-PC
    CG34385-PD
    CG34385-PE
    dpr12-PC
    dpr12-PD
    dpr12-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5804712..5860831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136342.2 → NP_610186.2  defective proboscis extension response 12, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHB6
      Conserved Domains (3) summary
      cd00096
      Location:174 → 241
      Ig; Immunoglobulin domain
      smart00410
      Location:163 → 251
      IG_like; Immunoglobulin like
      cl11960
      Location:82 → 154
      Ig; Immunoglobulin domain

    2. NM_144205.5 → NP_652462.3  defective proboscis extension response 12, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652462.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H9, A2RVF7
      Conserved Domains (3) summary
      smart00409
      Location:86 → 183
      IG; Immunoglobulin
      pfam13927
      Location:193 → 271
      Ig_3; Immunoglobulin domain
      cd00096
      Location:204 → 208
      Ig; Ig strand B [structural motif]

    3. NM_001273787.1 → NP_001260716.1  defective proboscis extension response 12, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KED6
      Conserved Domains (3) summary
      smart00410
      Location:86 → 178
      IG_like; Immunoglobulin like
      pfam13927
      Location:188 → 266
      Ig_3; Immunoglobulin domain
      cd00096
      Location:86 → 89
      Ig; Ig strand A' [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KED6 A0A0B4KED6
    A0A0C4DHB6 A0A0C4DHB6
    A1Z6H9 A1Z6H9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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