stai stathmin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: staiprovided by FlyBase
Official Full Name: stathminprovided by FlyBase
Primary source: FLYBASE:FBgn0266521
Locus tag: Dmel_CG31641
See related: AllianceGenome:FB:FBgn0266521
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:LD33989; CG31641; CG5981; D-stat; Dmel\CG31641; LD33989; rdt; rdtp; SCG10-like; Stai
Summary: Enables tubulin binding activity. Involved in several processes, including border follicle cell migration; germ cell migration; and synaptic assembly at neuromuscular junction. Located in neuromuscular junction. Is expressed in several structures, including brain; central nervous system; germline cell; larval PNS glial cell; and peripheral nervous system. Orthologous to several human genes including STMN1 (stathmin 1) and STMN2 (stathmin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26B5-26B7; 2-18 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6100377..6124653)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6100377..6124653)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data define a required function for Stathmin during synapse maintenance in a model system in which there is only a single stathmin gene.
Title: Stathmin is required for stability of the Drosophila neuromuscular junction.
the single Drosophila stathmin gene codes for a stathmin family similar to the multigene vertebrate one, but with particular tubulin binding properties
Title: Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries.
Microtubule-destabilizing protein directly involved in nervous system formation
Title: Drosophila stathmin: a microtubule-destabilizing factor involved in nervous system formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 6101131-6101639 mobile_element_type = transposon:S{}312

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stathmin

Names: CG31641-PA; CG31641-PB; CG31641-PC; CG31641-PD; CG31641-PE; D-stathmin; redtape; stai-PA; stai-PB; stai-PC; stai-PD; stai-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6100377..6124653

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273193.1 → NP_001260122.1 stathmin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260122.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPK0, Q9GQR3

Conserved Domains (2) summary

pfam00836
Location:59 → 188

Stathmin; Stathmin family

cl00391
Location:163 → 234

beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...
NM_164682.3 → NP_723156.1 stathmin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723156.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GQR3, Q9GQR5

Related

FBpp0078827

Conserved Domains (2) summary

pfam00836
Location:14 → 143

Stathmin; Stathmin family

cl00391
Location:118 → 189

beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...
NM_164683.3 → NP_723157.1 stathmin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723157.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPK0, Q9GQR3

Related

FBpp0078828

Conserved Domains (2) summary

pfam00836
Location:59 → 188

Stathmin; Stathmin family

cl00391
Location:163 → 234

beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...
NM_164684.3 → NP_723158.1 stathmin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723158.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RX3, Q9VMH3

Related

FBpp0078829

Conserved Domains (1) summary

pfam00836
Location:55 → 189

Stathmin; Stathmin family
NM_001258983.2 → NP_001245912.1 stathmin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245912.1

Status: REVIEWED

UniProtKB/TrEMBL

D1Z391, M9NEA1

Conserved Domains (2) summary

pfam00836
Location:138 → 267

Stathmin; Stathmin family

cl00391
Location:242 → 313

beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...