Lk6 Lk6 kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lk6provided by FlyBase
Official Full Name: Lk6 kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0017581
Locus tag: Dmel_CG17342
See related: AllianceGenome:FB:FBgn0017581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.84; CG17342; CG6929; Dmel\CG17342; lk6; LK6; MESR8; MNK/LK6
Summary: Enables mitogen-activated protein kinase binding activity and protein serine/threonine kinase activity. Involved in microtubule-based process and regulation of growth. Located in cytoplasm; microtubule cytoskeleton; and nuclear envelope. Is expressed in several structures, including fat body; ganglia; gland; larval longitudinal connective; and larval neurosecretory neurons. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1) and MKNK2 (MAPK interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 86E17-86E18; 3-51 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11750931..11764457, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7576653..7590179, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that it is via Lk6, regulators of the translation factor eIF4E, FOXO and TOR also converge to regulate protein synthesis.
Title: Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.
Lk6 function is dispensable under a high protein diet, whereas loss of Lk6 function causes a significant growth reduction when the amino acid content in the diet is reduced.
Title: Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E.
Lk6 exerts a tight control on Eukaryotic initiation factor 4E phosphorylation and is necessary for normal growth and development.
Title: Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development.
results show that LK6 binds to ERK and is activated by ERK signalling and it is responsible for phosphorylating eIF4E in Drosophila
Title: The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Lk6 kinase

Names: CG17342-PA; CG17342-PB; Lk6-PA; Lk6-PB

NP_651986.2

EC 2.7.11.1

EC 2.7.11.17

NP_731624.1

EC 2.7.11.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11750931..11764457 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143729.3 → NP_651986.2 Lk6 kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651986.2

Status: REVIEWED

UniProtKB/TrEMBL

Q94548, Q9VGI4

Related

FBpp0082008

Conserved Domains (2) summary

smart00220
Location:117 → 403

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14090
Location:115 → 403

STKc_Mnk; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases
NM_169423.3 → NP_731624.1 Lk6 kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731624.1

Status: REVIEWED

UniProtKB/TrEMBL

Q94548, Q9VGI5

Related

FBpp0082009

Conserved Domains (2) summary

smart00220
Location:65 → 351

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14090
Location:63 → 351

STKc_Mnk; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases