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    Sbp2 SECIS-binding protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sbp2provided by FlyBase
    Official Full Name
    SECIS-binding protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0087039
    Locus tag
    Dmel_CG7066
    See related
    AllianceGenome:FB:FBgn0087039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7066; Dmel\CG7066; SBP2
    Summary
    Enables RNA stem-loop binding activity and selenocysteine insertion sequence binding activity. Involved in selenocysteine incorporation. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human SECISBP2 (SECIS binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sbp2 in Genome Data Viewer
    Location:
    66C5-66C5; 3-24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8304157..8305325)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8297257..8298425)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 66a Neighboring gene Bax Inhibitor-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A taste receptor required for the caffeine response in vivo. Moon SJ, et al. Curr Biol, 2006 Sep 19. PMID 16979558
    2. A short motif in Drosophila SECIS Binding Protein 2 provides differential binding affinity to SECIS RNA hairpins. Takeuchi A, et al. Nucleic Acids Res, 2009 Apr. PMID 19223320, Free PMC Article
    3. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Lobanov AV, et al. Protein Sci, 2008 Jan. PMID 18156471, Free PMC Article
    4. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. Hirosawa-Takamori M, et al. FASEB J, 2009 Jan. PMID 18772345, Free PMC Article
    5. Selenoproteins: molecular pathways and physiological roles. Labunskyy VM, et al. Physiol Rev, 2014 Jul. PMID 24987004, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables selenocysteine insertion sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables selenocysteine insertion sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SECIS-binding protein 2
    Names
    CG7066-PA
    SECIS binding protein 2
    SECIS-binding protein2
    Sbp2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8304157..8305325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139947.3 → NP_648204.1  SECIS-binding protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZV6, Q9VSH1
      Related
      FBpp0076430
      Conserved Domains (1) summary
      pfam01248
      Location:200 → 290
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSH1 Q9VSH1

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