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    fabp fatty acid binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fabpprovided by FlyBase
    Official Full Name
    fatty acid binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037913
    Locus tag
    Dmel_CG6783
    See related
    AllianceGenome:FB:FBgn0037913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey234; anon-WO0140519.12; BcDNA:RH06221; BcDNA:RH46282; BcDNA:RH49003; BcDNA:SD12036; CG31305; CG31305-PI; CG6783; CT21061; dFabp; dFABP; Dmel\CG6783; Fabp; FABP
    Summary
    Predicted to enable fatty acid binding activity. Involved in chitin-based cuticle development and long-term memory. Located in cytosol and nucleoplasm. Is expressed in adult brain; adult brain cell body rind; adult head; adult heart; and glial cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G; hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including FABP4 (fatty acid binding protein 4) and FABP9 (fatty acid binding protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fabp in Genome Data Viewer
    Location:
    86E10-86E10; 3-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11559896..11567054, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7385618..7392776, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene scheggia Neighboring gene Multidrug resistance protein 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic to nuclear localization of fatty-acid binding protein correlates with specific forms of long-term memory in Drosophila. Gerstner JR, et al. Commun Integr Biol, 2011 Sep. PMID 22046481, Free PMC Article
    2. The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport. Cheng YY, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Dec. PMID 31404652
    3. Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila. Gerstner JR, et al. J Neurosci Res, 2017 Aug. PMID 27320125, Free PMC Article
    4. Roles of Drosophila fatty acid-binding protein in development and behavior. Jang S, et al. Biochem Biophys Res Commun, 2022 Apr 9. PMID 35176630
    5. Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila. Gerstner JR, et al. PLoS One, 2011 Jan 27. PMID 21298037, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles of Drosophila fatty acid-binding protein in development and behavior.
      Title: Roles of Drosophila fatty acid-binding protein in development and behavior.
    2. This study showed that the unliganded archetypal Drosophila brain-type fatty acid-binding protein (dFABP) possesses a stronger binding affinity than its liganded counterpart for empty nanodiscs. The crystallographic temperature factor data suggest enhanced alphaII helix dynamics upon Long-chain fatty acids binding.
      Title: The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport.
    3. These studies suggest that alterations in Fabp levels and/or activity may be associated with sleep disturbances in Alzheimer disease.
      Title: Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid binding protein
    Names
    CG6783-PA
    CG6783-PB
    CG6783-PC
    fabp-PA
    fabp-PB
    fabp-PC
    fatty acid bindin protein
    fatty-acid binding protein
    fatty-acid-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11559896..11567054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032008.2 → NP_001027179.1  fatty acid binding protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INK3
      Conserved Domains (1) summary
      pfam00061
      Location:7 → 107
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001032009.2 → NP_001027180.1  fatty acid binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGA2, Q9VGM2
      Conserved Domains (1) summary
      cd19852
      Location:2 → 129
      FABP_pancrustacea; fatty acid-binding protein similar to Locusta migratoria FABP (Lm-FABP)

    3. NM_001032010.2 → NP_001027181.1  fatty acid binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INK2
      Conserved Domains (1) summary
      pfam00061
      Location:5 → 115
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGA2 Q8IGA2
    Q8INK2 Q8INK2
    Q8INK3 Q8INK3
    Q9VGM2 Q9VGM2

    Gene LinkOut

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