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    Dic1 Dicarboxylate carrier 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dic1provided by FlyBase
    Official Full Name
    Dicarboxylate carrier 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027610
    Locus tag
    Dmel_CG8790
    See related
    AllianceGenome:FB:FBgn0027610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02431; CG8790; DmDic1p; Dmel\CG8790
    Summary
    Enables C4-dicarboxylate transmembrane transporter activity and inorganic anion transmembrane transporter activity. Involved in C4-dicarboxylate transport; inorganic anion transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dic1 in Genome Data Viewer
    Location:
    87E8-87E8; 3-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13364938..13369278)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9190660..9195000)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pyrokinin 2 receptor 1 Neighboring gene methuselah-like 12 Neighboring gene Elongator complex protein 6 Neighboring gene Chemosensory protein A 87a Neighboring gene Lipase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel subfamily of mitochondrial dicarboxylate carriers from Drosophila melanogaster: biochemical and computational studies. Iacopetta D, et al. Biochim Biophys Acta, 2011 Mar. PMID 21130726
    2. Functional Validation of Candidate Genes Detected by Genomic Feature Models. Rohde PD, et al. G3 (Bethesda), 2018 May 4. PMID 29519937, Free PMC Article
    3. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Bolukbasi E, et al. Open Biol, 2012 Jan. PMID 22645656, Free PMC Article
    4. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    5. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxaloacetate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in malate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiosulfate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dicarboxylate carrier 1
    Names
    CG8790-PA
    CG8790-PB
    CG8790-PC
    Dic1-PA
    Dic1-PB
    Dic1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13364938..13369278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169510.3 → NP_731793.1  dicarboxylate carrier 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y166
      Related
      FBpp0082215
      Conserved Domains (2) summary
      PTZ00169
      Location:13 → 273
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:189 → 278
      Mito_carr; Mitochondrial carrier protein

    2. NM_001300384.1 → NP_001287313.1  dicarboxylate carrier 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y166
      Conserved Domains (2) summary
      PTZ00169
      Location:13 → 273
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:189 → 278
      Mito_carr; Mitochondrial carrier protein

    3. NM_142022.4 → NP_650279.1  dicarboxylate carrier 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y166
      Related
      FBpp0082216
      Conserved Domains (2) summary
      PTZ00169
      Location:13 → 273
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:189 → 278
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y166 Q9Y166

    Gene LinkOut

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