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    Pkg21D Protein kinase, cGMP-dependent at 21D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkg21Dprovided by FlyBase
    Official Full Name
    Protein kinase, cGMP-dependent at 21Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000442
    Locus tag
    Dmel_CG3324
    See related
    AllianceGenome:FB:FBgn0000442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3324; cGMP; dg1; Dg1; DG1; Dmel\CG3324; PKG; PKG 21D; PKG-21D; Pkg1; PKG1; pkg21D; PKG21D
    Summary
    Enables cGMP-dependent protein kinase activity. Involved in larval somatic muscle development. Located in cytoplasm. Is expressed in Malpighian tubule; embryonic hindgut; embryonic large intestine; embryonic/larval corpus allatum; and head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pkg21D in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (786153..790798, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (786153..790798, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 21a Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45259 Neighboring gene Nnf1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase. Foster JL, et al. J Biol Chem, 1996 Sep 20. PMID 8798533
    2. Characterization of a novel stimulus-induced glial calcium wave in Drosophila larval peripheral segmental nerves and its role in PKG-modulated thermoprotection. Krill JL, et al. J Neurogenet, 2021 Sep. PMID 34309496
    3. cGMP-dependent protein kinase genes in Drosophila. Kalderon D, et al. J Biol Chem, 1989 Jun 25. PMID 2732245
    4. Cloning, sequence, and expression of the Drosophila cAMP-dependent protein kinase catalytic subunit gene. Foster JL, et al. J Biol Chem, 1988 Feb 5. PMID 2828348
    5. A novel role for the nitric oxide-cGMP signaling pathway: the control of epithelial function in Drosophila. Dow JA, et al. Am J Physiol, 1994 May. PMID 8203655

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DG1 expression greatly enhanced fluid transport by the tubule in response to exogenous cGMP
      Title: Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase, cGMP-dependent at 21D
    Names
    CG3324-PA
    Pkg21D-PA
    cGMP-dependent protein kinase 21D
    NP_477213.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      786153..790798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057865.4 → NP_477213.1  protein kinase, cGMP-dependent at 21D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477213.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03042, Q24566, Q9V403
      Related
      FBpp0077706
      Conserved Domains (5) summary
      smart00133
      Location:719 → 760
      S_TK_X; Extension to Ser/Thr-type protein kinases
      COG0664
      Location:183 → 386
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:304 → 419
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:463 → 724
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
      pfam00069
      Location:457 → 717
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03042.2 Q03042

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