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    Dred Dctn1-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dredprovided by FlyBase
    Official Full Name
    Dctn1-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036882
    Locus tag
    Dmel_CG9279
    See related
    AllianceGenome:FB:FBgn0036882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9279; Dmel\CG9279; P150B
    Summary
    Predicted to be involved in establishment of mitotic spindle orientation; intracellular protein transport; and nuclear migration. Predicted to be part of dynactin complex. Predicted to be active in axon; kinetochore; and spindle pole. Is expressed in several structures, including embryonic/larval midgut primordium; fat body/gonad primordium; foregut primordium; plasmatocyte primordium; and posterior endoderm. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Dred in Genome Data Viewer
    Location:
    76B6-76B6; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19538425..19544205, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19531525..19537272, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 76Bc Neighboring gene Cuticular protein 76Bd Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43885 Neighboring gene uncharacterized protein Neighboring gene Listerin E3 ubiquitin protein ligase 1 Neighboring gene Reduction in Cnn dots 7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced levels of ALS gene DCTN1 induce motor defects in Drosophila. Borg R, et al. Front Neurosci, 2023. PMID 37360176, Free PMC Article
    2. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article
    3. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
    4. The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance. Prokop A. Neural Dev, 2013 Sep 8. PMID 24010872, Free PMC Article
    5. Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models. Bussmann J, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28213160

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dctn1-related
    Names
    CG9279-PB
    CG9279-PC
    Dred-PB
    Dred-PC
    Dynactin1 p150 B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19538425..19544205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168801.2 → NP_730426.1  Dctn1-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQV2, Q86NU4
      Related
      FBpp0074744
      Conserved Domains (5) summary
      COG1196
      Location:422 → 1276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5244
      Location:7 → 642
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:10 → 74
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:702 → 965
      Dynactin; Dynein associated protein
      cl23943
      Location:422 → 490
      PCRF; PCRF domain

    2. NM_140867.3 → NP_649124.1  Dctn1-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQV2, Q86NU4
      Related
      FBpp0304997
      Conserved Domains (5) summary
      COG1196
      Location:422 → 1276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5244
      Location:7 → 642
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:10 → 74
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:702 → 965
      Dynactin; Dynein associated protein
      cl23943
      Location:422 → 490
      PCRF; PCRF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQV2 Q7JQV2
    Q86NU4 Q86NU4

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