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    CG2121 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35814, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2121provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033289
    Locus tag
    Dmel_CG2121
    See related
    AllianceGenome:FB:FBgn0033289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8698; Dmel\CG2121
    Summary
    Predicted to enable potassium channel regulator activity and transmembrane transporter activity. Involved in muscle contraction. Predicted to be active in plasma membrane and striated muscle dense body. Is expressed in adult head; embryonic somatic muscle cell; and larval somatic muscle cell. Orthologous to human UNC93A (unc-93 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2121 in Genome Data Viewer
    Location:
    44C4-44C6; 2-58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8396397..8411767, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4283902..4299272, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pou domain motif 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article
    2. Sleep and wakefulness modulate gene expression in Drosophila. Cirelli C, et al. J Neurochem, 2005 Sep. PMID 16001966
    3. Control of daily transcript oscillations in Drosophila by light and the circadian clock. Wijnen H, et al. PLoS Genet, 2006 Mar. PMID 16565745, Free PMC Article
    4. Aβ42 Expressing Drosophila melanogaster Model for Alzheimer's Disease: Quantitative Proteomics Identifies Altered Protein Dynamics of Relevance to Neurodegeneration. Deolankar SC, et al. OMICS, 2022 Jan. PMID 35006003
    5. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in striated muscle dense body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2121-PA
    CG2121-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8396397..8411767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144146.2 → NP_001137618.1  uncharacterized protein Dmel_CG2121, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZU1
      Conserved Domains (2) summary
      pfam07690
      Location:296 → 476
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:84 → 189
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_136534.3 → NP_610378.1  uncharacterized protein Dmel_CG2121, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3V9
      Related
      FBpp0087842
      Conserved Domains (2) summary
      pfam07690
      Location:282 → 462
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:70 → 175
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZU1 B7YZU1
    Q7K3V9 Q7K3V9

    Gene LinkOut

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