U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TTLL4A Tubulin tyrosine ligase-like 4A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47729, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TTLL4Aprovided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 4Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026147
    Locus tag
    Dmel_CG16833
    See related
    AllianceGenome:FB:FBgn0026147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD13681; CG16833; DmCG16833; Dmel\CG16833; LD13681; TTLL4
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in wound healing. Predicted to be active in ciliary basal body. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TTLL4A in Genome Data Viewer
    Location:
    32C1-32C1; 2-44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10989401..10997897)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10989401..10997897)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene SCAR Neighboring gene P-element induced wimpy testis Neighboring gene uncharacterized protein Neighboring gene aubergine Neighboring gene lectin-33A Neighboring gene Ribosomal protein L9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Cox DN, et al. Genes Dev, 1998 Dec 1. PMID 9851978, Free PMC Article
    2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    3. Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex. Duncan EJ, et al. Genome Res, 2010 Jul. PMID 20458100, Free PMC Article
    4. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article
    5. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Murray MJ, et al. Dev Biol, 2012 Dec 1. PMID 23000359

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tubulin tyrosine ligase-like 4A
    Names
    CG16833-PD
    CG16833-PE
    CG16833-PF
    CG16833-PG
    CG16833-PH
    CG16833-PI
    CG16833-PK
    CG16833-PL
    CG16833-PM
    CG16833-PN
    TTLL4A-PD
    TTLL4A-PE
    TTLL4A-PF
    TTLL4A-PG
    TTLL4A-PH
    TTLL4A-PI
    TTLL4A-PK
    TTLL4A-PL
    TTLL4A-PM
    TTLL4A-PN
    NP_001162946.1
    NP_001162947.1
    NP_001245968.1
    NP_001245970.1
    NP_001245971.1
    NP_001245972.1
    NP_001245973.1
    NP_652055.2
    NP_723642.2
    NP_723643.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10989401..10997897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259043.2 → NP_001245972.1  tubulin tyrosine ligase-like 4A, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NCT3, Q8IGW4
      Conserved Domains (1) summary
      pfam03133
      Location:371 → 665
      TTL; Tubulin-tyrosine ligase family

    2. NM_164954.3 → NP_723643.2  tubulin tyrosine ligase-like 4A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723643.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB2
      Conserved Domains (1) summary
      pfam03133
      Location:614 → 908
      TTL; Tubulin-tyrosine ligase family

    3. NM_164953.3 → NP_723642.2  tubulin tyrosine ligase-like 4A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723642.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB2
      Conserved Domains (1) summary
      pfam03133
      Location:614 → 908
      TTL; Tubulin-tyrosine ligase family

    4. NM_143798.4 → NP_652055.2  tubulin tyrosine ligase-like 4A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652055.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGW4, Q9VKL9
      Conserved Domains (1) summary
      pfam03133
      Location:371 → 665
      TTL; Tubulin-tyrosine ligase family

    5. NM_001169476.2 → NP_001162947.1  tubulin tyrosine ligase-like 4A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB2
      Conserved Domains (1) summary
      pfam03133
      Location:614 → 908
      TTL; Tubulin-tyrosine ligase family

    6. NM_001169475.2 → NP_001162946.1  tubulin tyrosine ligase-like 4A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGW4, Q9VKL9
      Conserved Domains (1) summary
      pfam03133
      Location:371 → 665
      TTL; Tubulin-tyrosine ligase family

    7. NM_001259042.2 → NP_001245971.1  tubulin tyrosine ligase-like 4A, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEE5
      Conserved Domains (1) summary
      pfam03133
      Location:614 → 908
      TTL; Tubulin-tyrosine ligase family

    8. NM_001259041.2 → NP_001245970.1  tubulin tyrosine ligase-like 4A, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NCT3, Q8IGW4
      Conserved Domains (1) summary
      pfam03133
      Location:371 → 665
      TTL; Tubulin-tyrosine ligase family

    9. NM_001259044.2 → NP_001245973.1  tubulin tyrosine ligase-like 4A, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEE5
      Conserved Domains (1) summary
      pfam03133
      Location:614 → 908
      TTL; Tubulin-tyrosine ligase family

    10. NM_001259039.2 → NP_001245968.1  tubulin tyrosine ligase-like 4A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEE5
      Conserved Domains (1) summary
      pfam03133
      Location:614 → 908
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCT3 M9NCT3
    M9NEE5 M9NEE5
    Q8IGW4 Q8IGW4
    Q8IPB2 Q8IPB2
    Q95TA0 Q95TA0
    Q9VKL9 Q9VKL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools