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    CG3860 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3860provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034951
    Locus tag
    Dmel_CG3860
    See related
    AllianceGenome:FB:FBgn0034951
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3860
    Summary
    Predicted to enable sterol binding activity. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including adult head; ganglia; gastric caecum; gonad; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to several human genes including OSBPL2 (oxysterol binding protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3860 in Genome Data Viewer
    Location:
    60B1-60B1; 2-106 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23992138..23995055, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19879661..19882578, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase Neighboring gene PAS kinase Neighboring gene mir-1009 stem loop Neighboring gene Obscurin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. Ma Z, et al. Development, 2010 Nov. PMID 20943709
    2. The anaphase promoting complex/cyclosome is required during development for modified cell cycles. Kashevsky H, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12169670, Free PMC Article
    3. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. Jiang K, et al. PLoS Biol, 2016 Feb. PMID 26863604, Free PMC Article
    4. Neuronal identity defines α-synuclein and tau toxicity. Praschberger R, et al. Neuron, 2023 May 17. PMID 36948206, Free PMC Article
    5. In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain. Uçkun E, et al. J Mol Biol, 2021 Nov 19. PMID 34624297

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3860-PA
    CG3860-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23992138..23995055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138021.3 → NP_611865.1  uncharacterized protein Dmel_CG3860, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1D9
      Related
      FBpp0072110
      Conserved Domains (1) summary
      pfam01237
      Location:26 → 439
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001299873.1 → NP_001286802.1  uncharacterized protein Dmel_CG3860, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGH8
      Conserved Domains (1) summary
      pfam01237
      Location:26 → 441
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGH8 A0A0B4LGH8
    Q9W1D9 Q9W1D9

    Gene LinkOut

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