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    Hel89B Helicase 89B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hel89Bprovided by FlyBase
    Official Full Name
    Helicase 89Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022787
    Locus tag
    Dmel_CG4261
    See related
    AllianceGenome:FB:FBgn0022787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    89B; BTAF1; CG4261; Dmel\CG4261; HEL89B; Helicase89B; Mot1
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and TBP-class protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including adult heart; antennal lobe hub; anterior endoderm; cuboidal/columnar epithelium; and ganglia. Orthologous to human BTAF1 (B-TFIID TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hel89B in Genome Data Viewer
    Location:
    89A11-89A11; 3-58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15973298..15983451)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11799020..11809173)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Retinoblastoma-family protein 2 Neighboring gene moira Neighboring gene long non-coding RNA:CR44133 Neighboring gene serpent Neighboring gene long non-coding RNA:CR42839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental genetics. Living with bad architecture. Lovell-Badge R. Nature, 1995 Aug 31. PMID 7651530
    2. Expanding the Mot1 subfamily: 89B helicase encodes a new Drosophila melanogaster SNF2-related protein which binds to multiple sites on polytene chromosomes. Goldman-Levi R, et al. Nucleic Acids Res, 1996 Aug 15. PMID 8774890, Free PMC Article
    3. TAF(II)170 interacts with the concave surface of TATA-binding protein to inhibit its DNA binding activity. Pereira LA, et al. Mol Cell Biol, 2001 Nov. PMID 11585931, Free PMC Article
    4. High affinity interaction of yeast transcriptional regulator, Mot1, with TATA box-binding protein (TBP). Adamkewicz JI, et al. J Biol Chem, 2001 Apr 13. PMID 11278722
    5. Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location. Yu J, et al. Dev Biol, 2002 Apr 15. PMID 11944949

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    helicase 89B
    Names
    89B helicase
    CG4261-PB
    CG4261-PC
    Hel89B-PB
    Hel89B-PC
    Helicase89B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15973298..15983451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169693.2 → NP_732097.2  helicase 89B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732097.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q71V44, Q9VF02
      Conserved Domains (5) summary
      cd00046
      Location:1370 → 1514
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:1353 → 1662
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1689 → 1813
      Helicase_C; Helicase conserved C-terminal domain
      pfam12054
      Location:654 → 1138
      DUF3535; Domain of unknown function (DUF3535)
      sd00044
      Location:395 → 420
      HEAT; HEAT repeat [structural motif]

    2. NM_001300422.1 → NP_001287351.1  helicase 89B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q71V44, Q9VF02
      Conserved Domains (5) summary
      cd00046
      Location:1370 → 1514
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:1353 → 1662
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1689 → 1813
      Helicase_C; Helicase conserved C-terminal domain
      pfam12054
      Location:654 → 1138
      DUF3535; Domain of unknown function (DUF3535)
      sd00044
      Location:395 → 420
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71V44 Q71V44
    Q86NV8 Q86NV8
    Q8IG93 Q8IG93
    Q9VF02 Q9VF02

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