eIF4A eukaryotic translation initiation factor 4A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF4Aprovided by FlyBase
Official Full Name: eukaryotic translation initiation factor 4Aprovided by FlyBase
Primary source: FLYBASE:FBgn0001942
Locus tag: Dmel_CG9075
See related: AllianceGenome:FB:FBgn0001942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2439; 9075; anon-26Aa; anon26A; CG9075; deIF4A; Dm-eIF4A; Dmel\CG9075; DmRH2; eIF 4A; eif-4a; eIF-4a; eIF-4A; Eif-4a; EIF-4a; EIF-4A; eIF-4a-I; eif4a; eif4A; eiF4A; eIF4a; Eif4a; EiF4A; EIF4A; eIF4A-I; eIF4AI; l(2)02439; l(2)162; l(2)26Ac; l(2)gdh-4; l(2)k01501; l(2L)162; L(2L)162; pecan; Su(dpp)YE9
Summary: Enables SMAD binding activity. Involved in several processes, including female germ-line stem cell asymmetric division; pole cell formation; and regulation of alternative mRNA splicing, via spliceosome. Located in P granule and cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; imaginal disc; and larval brain. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to several human genes including EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26B2-26B2; 2-18 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5981764..5985909)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5981764..5985909)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.
Title: Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.
our data identify the eIF4F complex as an important upstream regulator of TORC1, which acts via TSC2 to inactivate TORC1 upon withdrawal of amino acids
Title: eIF4A inactivates TORC1 in response to amino acid starvation.
eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary.
Title: eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary.
The results suggest that the eIF4A gene is under the control of the DREF pathway and DREF is therefore involved in the regulation of protein synthesis.
Title: Identification of the Drosophila eIF4A gene as a target of the DREF transcription factor.
dIF4A is a maternal-effect suppressor of decapentalplegic.
Title: A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in Drosophila.
eIF4A has a novel function as a specific inhibitor of Dpp signalling that mediates the degradation of SMAD homologues.
Title: A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation.
identification of eIF4AIII and Barentsz as components of a conserved protein complex that is essential for mRNA localization in flies and nonsense-mediated mRNA decay in mammals
Title: An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0207 (e-PCR)
- UniSTS:30531

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 5985132-5985168 mobile_element_type = transposon:blood{}5207

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in female germ-line stem cell asymmetric division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 4A

Names: CG9075-PA; CG9075-PB; CG9075-PC; CG9075-PD; CG9075-PE; CG9075-PF; eIF4A-PA; eIF4A-PB; eIF4A-PC; eIF4A-PD; eIF4A-PE; eIF4A-PF; eukaryotic initiation factor 4A; translation initiation factor 4A

NP_001245907.1

EC 3.6.4.13

NP_001260117.1

EC 3.6.4.13

NP_476595.1

EC 3.6.4.13

NP_723137.1

EC 3.6.4.13

NP_723138.1

EC 3.6.4.13

NP_723139.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5981764..5985909

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258978.3 → NP_001245907.1 eukaryotic translation initiation factor 4A, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245907.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV9, Q02748, Q9U9Y6, Q9VMJ8

UniProtKB/TrEMBL

C9QP42, D3DMH8

Conserved Domains (3) summary

PTZ00424
Location:6 → 403

PTZ00424; helicase 45; Provisional

cd00268
Location:32 → 232

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:254 → 358

Helicase_C; Helicase conserved C-terminal domain
NM_164668.3 → NP_723137.1 eukaryotic translation initiation factor 4A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723137.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV9, Q02748, Q9U9Y6, Q9VMJ8

UniProtKB/TrEMBL

C9QP42, D3DMH8

Related

FBpp0078806

Conserved Domains (3) summary

PTZ00424
Location:6 → 403

PTZ00424; helicase 45; Provisional

cd00268
Location:32 → 232

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:254 → 358

Helicase_C; Helicase conserved C-terminal domain
NM_057247.5 → NP_476595.1 eukaryotic translation initiation factor 4A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476595.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV9, Q02748, Q9U9Y6, Q9VMJ8

UniProtKB/TrEMBL

C9QP42, D3DMH8

Related

FBpp0078807

Conserved Domains (3) summary

PTZ00424
Location:6 → 403

PTZ00424; helicase 45; Provisional

cd00268
Location:32 → 232

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:254 → 358

Helicase_C; Helicase conserved C-terminal domain
NM_164670.4 → NP_723139.1 eukaryotic translation initiation factor 4A, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723139.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV9, Q02748, Q9U9Y6, Q9VMJ8

UniProtKB/TrEMBL

C9QP42, D3DMH8

Related

FBpp0078809

Conserved Domains (3) summary

PTZ00424
Location:6 → 403

PTZ00424; helicase 45; Provisional

cd00268
Location:32 → 232

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:254 → 358

Helicase_C; Helicase conserved C-terminal domain
NM_001273188.1 → NP_001260117.1 eukaryotic translation initiation factor 4A, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260117.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV9, Q02748, Q9U9Y6, Q9VMJ8

UniProtKB/TrEMBL

C9QP42, D3DMH8

Conserved Domains (3) summary

PTZ00424
Location:6 → 403

PTZ00424; helicase 45; Provisional

cd00268
Location:32 → 232

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:254 → 358

Helicase_C; Helicase conserved C-terminal domain
NM_164669.3 → NP_723138.1 eukaryotic translation initiation factor 4A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723138.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV9, Q02748, Q9U9Y6, Q9VMJ8

UniProtKB/TrEMBL

C9QP42, D3DMH8

Related

FBpp0078808

Conserved Domains (3) summary

PTZ00424
Location:6 → 403

PTZ00424; helicase 45; Provisional

cd00268
Location:32 → 232

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:254 → 358

Helicase_C; Helicase conserved C-terminal domain