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    Sec31 Secretory 31 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec31provided by FlyBase
    Official Full Name
    Secretory 31provided by FlyBase
    Primary source
    FLYBASE:FBgn0033339
    Locus tag
    Dmel_CG8266
    See related
    AllianceGenome:FB:FBgn0033339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8266; Dmel\CG8266; dSec31p; sec31; SEC31; SEC31A
    Summary
    Predicted to enable structural molecule activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Located in Golgi stack and endoplasmic reticulum exit site. Is expressed in adult head. Used to study Halperin-Birk syndrome. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component) and SEC31B (SEC31 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec31 in Genome Data Viewer
    Location:
    44F3-44F3; 2-59 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8893613..8898798)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4781118..4786303)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dynactin 2, p50 subunit Neighboring gene antisense RNA:CR45202 Neighboring gene anastral spindle 2 Neighboring gene uncharacterized protein Neighboring gene MRG/MORF4L binding protein Neighboring gene G protein gamma subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SEC31A mutation affects ER homeostasis, causing a neurological syndrome. Halperin D, et al. J Med Genet, 2019 Mar. PMID 30464055
    2. Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif. Ivan V, et al. Mol Biol Cell, 2008 Oct. PMID 18614796, Free PMC Article
    3. Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila. Iyer SC, et al. J Cell Sci, 2013 Oct 15. PMID 23902691, Free PMC Article
    4. Alcohol Activates Scabrous-Notch to Influence Associated Memories. Petruccelli E, et al. Neuron, 2018 Dec 5. PMID 30482693, Free PMC Article
    5. Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis. Matsuura Y, et al. Int J Mol Sci, 2024 Apr 20. PMID 38674111, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response HMP PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 31
    Names
    CG8266-PA
    CG8266-PB
    CG8266-PC
    CG8266-PD
    Sec31 ortholog
    Sec31-PA
    Sec31-PB
    Sec31-PC
    Sec31-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8893613..8898798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299286.1 → NP_001286215.1  secretory 31, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEZ1, Q5U0U9
      Conserved Domains (5) summary
      COG2319
      Location:35 → 334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:11 → 61
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80 → 329
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:570 → 690
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl23782
      Location:811 → 873
      RCR; Chitin synthesis regulation, resistance to Congo red

    2. NM_001299285.1 → NP_001286214.1  secretory 31, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEY1, Q5U0U9
      Conserved Domains (5) summary
      COG2319
      Location:35 → 334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:11 → 61
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80 → 329
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:569 → 689
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl23782
      Location:810 → 872
      RCR; Chitin synthesis regulation, resistance to Congo red

    3. NM_165630.3 → NP_724716.1  secretory 31, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7J6, Q5U0U9
      Related
      FBpp0087724
      Conserved Domains (5) summary
      COG2319
      Location:35 → 334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:11 → 61
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80 → 329
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:551 → 671
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl23782
      Location:792 → 854
      RCR; Chitin synthesis regulation, resistance to Congo red

    4. NM_136570.4 → NP_610414.1  secretory 31, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7J7, Q5U0U9
      Related
      FBpp0087723
      Conserved Domains (5) summary
      COG2319
      Location:35 → 334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:11 → 61
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80 → 329
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:550 → 670
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl23782
      Location:791 → 853
      RCR; Chitin synthesis regulation, resistance to Congo red
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEY1 A0A0B4LEY1
    A0A0B4LEZ1 A0A0B4LEZ1
    A1Z7J6 A1Z7J6
    A1Z7J7 A1Z7J7
    Q5U0U9 Q5U0U9
    Q961K5 Q961K5

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