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    CG2616 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2616provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037512
    Locus tag
    Dmel_CG2616
    See related
    AllianceGenome:FB:FBgn0037512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2616
    Summary
    Predicted to enable glutathione transmembrane transporter activity. Predicted to be involved in glutathione import into mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to several human genes including SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2616 in Genome Data Viewer
    Location:
    84D13-84D13; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7722417..7724715)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3548139..3550437)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neuroligin 1 Neighboring gene long non-coding RNA:CR44260 Neighboring gene long non-coding RNA:CR44935 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
    2. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    3. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2616-PA
    CG2616-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7722417..7724715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300283.1 → NP_001287212.1  uncharacterized protein Dmel_CG2616, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI05
      Conserved Domains (1) summary
      pfam00153
      Location:230 → 321
      Mito_carr; Mitochondrial carrier protein

    2. NM_141474.3 → NP_649731.1  uncharacterized protein Dmel_CG2616, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI05
      Related
      FBpp0081235
      Conserved Domains (1) summary
      pfam00153
      Location:230 → 321
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI05 Q9VI05

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