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    Cyp4p2 Cytochrome P450 4p2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4p2provided by FlyBase
    Official Full Name
    Cytochrome P450 4p2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033395
    Locus tag
    Dmel_CG1944
    See related
    AllianceGenome:FB:FBgn0033395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4p2; CG1944; CYP4P2; Dmel\CG1944
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval fat body. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4p2 in Genome Data Viewer
    Location:
    45B7-45B7; 2-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9237512..9239831)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5125017..5127336)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45309 Neighboring gene long non-coding RNA:CR44451 Neighboring gene hikaru genki Neighboring gene Cytochrome P450 4p1 Neighboring gene Cytochrome P450 4p3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Social experience and pheromone receptor activity reprogram gene expression in sensory neurons. Deanhardt B, et al. G3 (Bethesda), 2023 Jun 1. PMID 36972331, Free PMC Article
    2. Cytochrome P450s Cyp4p1 and Cyp4p2 associated with the DDT tolerance in the Drosophila melanogaster strain 91-R. Seong KM, et al. Pestic Biochem Physiol, 2019 Sep. PMID 31400775
    3. ATF4 Responds to Metabolic Stress in Drosophila. Ok S, et al. Front Biosci (Landmark Ed), 2023 Dec 26. PMID 38179767
    4. Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila. Soulé S, et al. Nat Commun, 2020 Feb 20. PMID 32080190, Free PMC Article
    5. Transcriptome analysis of Drosophila melanogaster laboratory strains of different geographical origin after long-term laboratory maintenance. Zarubin M, et al. Ecol Evol, 2020 Jul. PMID 32760513, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4p2
    Names
    CG1944-PA
    Cyp4p2-PA
    cytochrome P450
    NP_610472.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9237512..9239831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136628.3 → NP_610472.1  cytochrome P450 4p2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V557
      Related
      FBpp0087672
      Conserved Domains (1) summary
      cl12078
      Location:63 → 514
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3YNE4 Q3YNE4
    Q9V557.1 Q9V557

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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