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    ND-15 NADH dehydrogenase (ubiquinone) 15 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-15provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 15 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031228
    Locus tag
    Dmel_CG11455
    See related
    AllianceGenome:FB:FBgn0031228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11455; Dmel\CG11455; dNDUFS5; NDUFS5; NIPM
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; endoderm anlage; larval muscle cell; and mesoderm. Orthologous to human NDUFS5 (NADH:ubiquinone oxidoreductase subunit S5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-15 in Genome Data Viewer
    Location:
    21B2-21B3; 2-0.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (114726..156030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (114726..156030)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cysteine rich with EGF like domains Neighboring gene Na[+]/H[+] hydrogen exchanger 1 Neighboring gene S-adenosylmethionine Synthetase Neighboring gene antisense RNA:CR44969 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44185 Neighboring gene long non-coding RNA:CR44186 Neighboring gene Glutamine synthetase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene oven mitt Neighboring gene uncharacterized protein Neighboring gene Pseudouridine synthase 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene split ends

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. Klein P, et al. EMBO J, 2014 Feb 18. PMID 24473149, Free PMC Article
    2. TRAP1 rescues PINK1 loss-of-function phenotypes. Zhang L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525905, Free PMC Article
    3. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. Vilain S, et al. PLoS Genet, 2012 Jan. PMID 22242018, Free PMC Article
    4. Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics. Borchardt LA, et al. Int J Mol Sci, 2023 Jan 17. PMID 36768163, Free PMC Article
    5. Senescent glia link mitochondrial dysfunction and lipid accumulation. Byrns CN, et al. Nature, 2024 Jun. PMID 38839958, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 116518-116976 mobile_element_type = transposon:INE-1{}2496

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 15 kDa subunit
    Names
    CG11455-PA
    CG11455-PB
    CG11455-PC
    CG11455-PD
    CG11455-PF
    CG11455-PG
    CG11455-PH
    CG11455-PI
    CG11455-PJ
    CG11455-PK
    NADH ubiquinone oxidoreductase 15 kDa
    NADH-ubiquinone oxidoreductase 15 kDa subunit
    NADH:ubiquinone oxidoreductase 15 kDa subunit
    ND-15-PA
    ND-15-PB
    ND-15-PC
    ND-15-PD
    ND-15-PF
    ND-15-PG
    ND-15-PH
    ND-15-PI
    ND-15-PJ
    ND-15-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      114726..156030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272863.1 → NP_001259792.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    2. NM_001258886.1 → NP_001245815.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    3. NM_001272864.1 → NP_001259793.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBY4
      Conserved Domains (1) summary
      pfam10200
      Location:4 → 48
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    4. NM_001272866.1 → NP_001259795.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    5. NM_001272867.1 → NP_001259796.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    6. NM_164372.3 → NP_722613.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Related
      FBpp0077777
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    7. NM_001169371.2 → NP_001162842.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    8. NM_164371.3 → NP_722612.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Related
      FBpp0077776
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    9. NM_001272865.2 → NP_001259794.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBY4
      Conserved Domains (1) summary
      pfam10200
      Location:4 → 48
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    10. NM_001169370.2 → NP_001162841.1  NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162841.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C0
      Conserved Domains (1) summary
      pfam10200
      Location:21 → 79
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBY4 M9PBY4
    Q7K1C0 Q7K1C0

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