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    Agxt Alanine-glyoxylate aminotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agxtprovided by FlyBase
    Official Full Name
    Alanine-glyoxylate aminotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014031
    Locus tag
    Dmel_CG3926
    See related
    AllianceGenome:FB:FBgn0014031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AGXT; CG3926; dAgxt; dAGXT; Dm-Spat; Dmel\CG3926; spa; spat; Spat
    Summary
    Enables alanine-glyoxylate transaminase activity. Involved in glyoxylate catabolic process. Predicted to be active in peroxisome. Is expressed in adult head. Used to study primary hyperoxaluria type 1. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Agxt in Genome Data Viewer
    Location:
    6B1-6B1; 1-17 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6528948..6530726)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6422981..6424759)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Phenylalanine-GAA 1-1 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L7A Neighboring gene deltex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase. Han Q, et al. FEBS Lett, 2002 Sep 11. PMID 12220660, Free PMC Article
    2. Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster. Yang H, et al. BMC Nephrol, 2018 Jul 6. PMID 29980178, Free PMC Article
    3. The genomic organization of the region containing the Drosophila melanogaster rpL7a (Surf-3) gene differs from those of the mammalian and avian Surfeit loci. Armes N, et al. Mol Cell Biol, 1995 May. PMID 7739520, Free PMC Article
    4. Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. Wittkopp PJ, et al. Genetics, 2006 Jul. PMID 16702434, Free PMC Article
    5. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-serine-pyruvate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-glyoxylate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-glyoxylate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycine biosynthetic process, by transamination of glyoxylate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Alanine-glyoxylate aminotransferase
    Names
    Agxt-PA
    CG3926-PA
    serine pyruvate aminotransferase
    NP_511062.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6528948..6530726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078507.2 → NP_511062.1  Alanine-glyoxylate aminotransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP18, Q8T0J1, Q9W3Z3
      Related
      FBpp0070875, FBtr0070913
      Conserved Domains (1) summary
      cd06451
      Location:19 → 381
      AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24510 Q24510
    Q9W3Z3.1 Q9W3Z3

    Gene LinkOut

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