PolA1 DNA polymerase alpha subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PolA1provided by FlyBase
Official Full Name: DNA polymerase alpha subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0259113
Locus tag: Dmel_CG6349
See related: AllianceGenome:FB:FBgn0259113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 183 kDa pol alpha; AAB24152; CG6349; Ctf4-polalpha; Dmel\CG6349; Dmpol alpha; DmPolalpha; DNA pol alpha; DNA Pol-alpha180; DNA polalpha; DNA Polalpha-180; DNA polymerase alpha 180 kD; DNA-Polalpha; DNApol; DNApol-alpha; DNApol-alpha180; DNApola; DNApolalpha; DNApolalpha180; dpolalpha; dpolalphap180; E(mus304); Pol; pol alpha; Pol alpha; Pol-alpha180; POLA; polalpha; Polalpha; Polalpha 180KDa; POlalpha 180kDa; Polalpha180; polalphap180
Summary: Enables 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication proofreading. Located in nucleus. Part of alpha DNA polymerase:primase complex. Is expressed in follicle cell; nurse cell; organism; and ovary. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93F2-93F2; 3-73 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21666562..21671750, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17492284..17497472, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5'-DNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA exonuclease activity, producing 5'-phosphomonoesters	IDA Inferred from Direct Assay more info	PubMed
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication proofreading	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in lagging strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of alpha DNA polymerase:primase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha DNA polymerase:primase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA polymerase alpha subunit 1

Names: 180 kDa subunit; 180 kDa subunit of DNA polymerase alpha; 180 kDa subunit of polymerase-primase; 182-kDa polymerase subunit; CG6349-PA; DNA pol 180; DNA polymerase 180K; DNA polymerase alpha; DNA polymerase alpha 148,000 alpha subunit; DNA polymerase alpha 180 kD; DNA polymerase alpha 180-kDa subunit; DNA polymerase alpha 180kD; DNA polymerase alpha 180kD subunit; DNA polymerase alpha 182,000 alpha subunit; DNA polymerase-alpha p180 subunit; DNA polymerase-primase 180 kda subunit; DNA-polymerase alpha; DNApol-alpha180; PolA1-PA; enhancer of mus304

NP_536736.2

EC 2.7.7.7

EC 3.1.11.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21666562..21671750 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080488.3 → NP_536736.2 DNA polymerase alpha subunit 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536736.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O77034, P26019, Q8T992, Q9VD90

Related

FBpp0083514

Conserved Domains (5) summary

cd05776
Location:567 → 789

DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase

cd05532
Location:852 → 1254

POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...

TIGR00592
Location:52 → 1237

pol2; DNA polymerase (pol2)

pfam08996
Location:1286 → 1459

zf-DNA_Pol; DNA Polymerase alpha zinc finger

pfam12254
Location:24 → 83

DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal