Hsp27 Heat shock protein 27 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp27provided by FlyBase
Official Full Name: Heat shock protein 27provided by FlyBase
Primary source: FLYBASE:FBgn0001226
Locus tag: Dmel_CG4466
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 27; 27K; 28; anon-WO0140519.69; CG4466; dHSP27; Dhsp27; Dmel23.6; Dmel\CG4466; DmHsp27; DmHSP27; hsp 27; Hsp 27; hsp-27; hsp26; hsp27; HSP27; hsp27/26; hsp28; Hsp28; HSP28; small hsp locus 67B
Orthologs: all
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Genomic context

Location:: 67B3-67B3; 3-29 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9384063..9385694)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9377163..9378794)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsp27 over expression protect against cadmium induced nephrotoxicity in Drosophila melanogaster.
Title: Hsp27 over expression protect against cadmium induced nephrotoxicity in Drosophila melanogaster.
Hsp27, a potential EcR target, protects nonylphenol-induced cellular and organismal toxicity in Drosophila melanogaster.
Title: Hsp27, a potential EcR target, protects nonylphenol-induced cellular and organismal toxicity in Drosophila melanogaster.
Altogether, the results characterize wild-type Hsp27 and its alpha-crystallin domain (ACD) arginine mutants and may give insight into protection mechanism of small heat shock proteins.
Title: Oligomerization and chaperone-like activity of Drosophila melanogaster small heat shock protein DmHsp27 and three arginine mutants in the alpha-crystallin domain.
The study evidenced the neuroprotective efficacy of hsp27 overexpression against prolonged dichlorvos exposure.
Title: Overexpression of hsp27 Rescued Neuronal Cell Death and Reduction in Life- and Health-Span in Drosophila melanogaster Against Prolonged Exposure to Dichlorvos.
We show that while Hsp70 or Hsp83 expression under normal or stress conditions was not affected by AR feeding, Hsp27 levels were elevated in AR-fed wild-type control as well as heat-shocked larvae
Title: Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster.
We propose that Atg7 acts downstream of Hsp27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila.
Title: Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila.
The functional similarities and differences of neuronal expression of hsp26 and hsp27 in adult Drosophila were demonstrated.
Title: The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila.
study identifies two distinct sets of sequences respectively mediating the nuclear import of Hsp27 and its association to nuclear speckles.
Title: The nuclear localization of Drosophila Hsp27 is dependent on a monopartite arginine-rich NLS and is uncoupled from its association to nuclear speckles.
The data suggest that the Drosophila HSP27 protein acts as a chaperone to provide cellular stress resistance, although its function may be limited to a subset of the stress response such as the starvation resistance.
Title: The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance.
Data show that overexpression of either heat-shock proteins 26 or 27 extended the mean lifespan by 30%, and the flies also displayed increased stress resistance.
Title: Multiple-stress analysis for isolation of Drosophila longevity genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 27

Names: CG4466-PA; CG4466-PB; Hsp 27; Hsp27-PA; Hsp27-PB; heat shock protein 237; heat shock protein hsp27; heatshock protein 27; hsp27; protein 27

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9384063..9385694

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300072.1 → NP_001287001.1 heat shock protein 27, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287001.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02518, Q9VSX6

UniProtKB/TrEMBL

X2JC82

Conserved Domains (1) summary

cd06526
Location:86 → 163

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_079276.4 → NP_524000.1 heat shock protein 27, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524000.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02518, Q9VSX6

UniProtKB/TrEMBL

X2JC82

Related

FBpp0076182

Conserved Domains (1) summary

cd06526
Location:86 → 163

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...